Version 5.4
Homo sapiens Gene: UBR1
Summary
InnateDB Gene IDBG-8138.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBR1
Gene Name ubiquitin protein ligase E3 component n-recognin 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000159459
Encoded Proteins
IDBP-8140
ubiquitin protein ligase E3 component n-recognin 1
IDBP-811133
ubiquitin protein ligase E3 component n-recognin 1
IDBP-745502
IDBP-746423
IDBP-745269
IDBP-746925
IDBP-745919
IDBP-746589
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:42942897-43106113
Strand Reverse strand
Band q15.2
Transcripts
ENST00000290650 ENSP00000290650
ENST00000546274 ENSP00000477932
ENST00000569971 ENSP00000455759
ENST00000564540 ENSP00000457879
ENST00000563239 ENSP00000456502
ENST00000566493
ENST00000569337 ENSP00000454962
ENST00000562173
ENST00000569243 ENSP00000457573
ENST00000569066 ENSP00000456327
ENST00000568782
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 61 [view]
Protein-Protein 61 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0070728 leucine binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0030163 protein catabolic process
GO:0032007 negative regulation of TOR signaling
GO:0071233 cellular response to leucine
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0000502 proteasome complex
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027272
View Gene Order
ENSBTAG00000021087
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.145209 Hs.591121
RefSeq NM_174916
HUGO
OMIM
CCDS CCDS10091
HPRD 09342
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca