Homo sapiens Gene: TAP1 | |||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||
InnateDB Gene | IDBG-81568.6 | ||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
Gene Symbol | TAP1 | ||||||||||||||||||||||||||||
Gene Name | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | ||||||||||||||||||||||||||||
Synonyms | ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1; RING4; TAP1*0102N; TAP1N | ||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000168394 | ||||||||||||||||||||||||||||
Encoded Proteins |
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
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Protein Structure | |||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||
Summary |
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq, Jul 2008] The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014] |
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Gene Information | |||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||
Genomic Location | Chromosome 6:32845209-32853978 | ||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||
Band | p21.32 | ||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||
REACTOME |
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
ER-Phagosome pathway pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
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KEGG |
Antigen processing and presentation pathway
ABC transporters pathway
Primary immunodeficiency pathway
Phagosome pathway
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INOH | |||||||||||||||||||||||||||||
PID NCI |
Direct p53 effectors
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Cross-References | |||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||
UniGene | |||||||||||||||||||||||||||||
RefSeq | NM_000593 NM_001292022 | ||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||
CCDS | CCDS4758 | ||||||||||||||||||||||||||||
HPRD | 01359 | ||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||