InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HLA-DOA

Summary

InnateDB Gene

IDBG-81729.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HLA-DOA

Gene Name

major histocompatibility complex, class II, DO alpha

Synonyms

HLA-DNA; HLA-DZA; HLADZ

Species

Homo sapiens

Ensembl Gene

ENSG00000204252

Encoded Proteins

IDBP-81731

major histocompatibility complex, class II, DO alpha

IDBP-81733

major histocompatibility complex, class II, DO alpha

IDBP-374860

major histocompatibility complex, class II, DO alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:33004178-33009612

Strand

Reverse strand

Band

p21.32

Transcripts

ENST00000229829	ENSP00000229829
ENST00000374813	ENSP00000363946
ENST00000450833	ENSP00000403896
ENST00000490305
ENST00000485901
ENST00000495532
ENST00000467465

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0023026	MHC class II protein complex binding
GO:0032395	MHC class II receptor activity

Biological Process

GO:0002587	negative regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0006955	immune response
GO:0007165	signal transduction
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045580	regulation of T cell differentiation

Cellular Component

GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042613	MHC class II protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024334

View Gene Order

ENSBTAG00000006490

Not yet available

Pathways

NETPATH

REACTOME

REACT_121399

MHC class II antigen presentation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

KEGG

hsa04514

Cell adhesion molecules (CAMs) pathway

hsa04612

Antigen processing and presentation pathway

hsa04940

Type I diabetes mellitus pathway

hsa05330

Allograft rejection pathway

hsa05320

Autoimmune thyroid disease pathway

hsa05322

Systemic lupus erythematosus pathway

hsa05332

Graft-versus-host disease pathway

hsa05310

Asthma pathway

hsa04672

Intestinal immune network for IgA production pathway

hsa05416

Viral myocarditis pathway

hsa05140

Leishmaniasis pathway

hsa05150

Staphylococcus aureus infection pathway

hsa05145

Toxoplasmosis pathway

hsa04145

Phagosome pathway

INOH

PID NCI

Cross-References

SwissProt

P06340

TrEMBL

F6WU08 X5CF87

UniProt Splice Variant

Entrez Gene

3111

UniGene

Hs.631991

RefSeq

NM_002119

HUGO

HGNC:4936

OMIM

142930

CCDS

CCDS4763

HPRD

IMGT

EMBL

AB005991 AB005992 AB005993 AB005994 AB005995 AB005996 AB005997 AB005998 AK290714 AK313551 AL645931 AL662845 AL805913 AY947479 AY947480 AY947481 BC013183 BX005422 CH471081 CR759795 CR759829 CR936909 KJ657694 KJ657696 KJ657697 M26039 M31525 X02882 Z81310

GenPept

AAA59716 AAA60075 AAH13183 AAX49509 AAX49510 AAX49511 AHW47931 AHW47965 AHW47982 BAA81787 BAA81788 BAA81789 BAA81790 BAA81791 BAA81792 BAA81793 BAA81794 BAF83403 BAG36327 CAA26635 CAB03594 CAI17494 CAI18036 CAI18546 CAM26122 CAP58470 CAQ07150 CAQ07430 EAX03668

RNA Seq Atlas

3111