Version 5.4
Homo sapiens Gene: DAGLB
Summary
InnateDB Gene IDBG-8175.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DAGLB
Gene Name diacylglycerol lipase, beta
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164535
Encoded Proteins
IDBP-8177
diacylglycerol lipase, beta
IDBP-363915
diacylglycerol lipase, beta
IDBP-363938
diacylglycerol lipase, beta
IDBP-363946
diacylglycerol lipase, beta
IDBP-363948
diacylglycerol lipase, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 23103940
[Mus musculus] DAGLB is a key metabolic hub within a lipid network that regulates proinflammatory responses in peritoneal macrophages.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 7:6409126-6484190
Strand Reverse strand
Band p22.1
Transcripts
ENST00000297056 ENSP00000297056
ENST00000425398 ENSP00000391171
ENST00000436575 ENSP00000404785
ENST00000454738 ENSP00000411746
ENST00000432248 ENSP00000410787
ENST00000462934
ENST00000482149
ENST00000497308
ENST00000479922
ENST00000483716
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004806 triglyceride lipase activity
GO:0046872 metal ion binding
Biological Process
GO:0006629 lipid metabolic process
GO:0007405 neuroblast proliferation
GO:0007596 blood coagulation
GO:0016042 lipid catabolic process
GO:0019369 arachidonic acid metabolic process
GO:0022008 neurogenesis
GO:0030168 platelet activation
GO:0042136 neurotransmitter biosynthetic process
Cellular Component
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039206
View Gene Order
ENSBTAG00000009236
Not yet available
Pathways
NETPATH
REACTOME
REACT_19308
Arachidonate production from DAG pathway
REACT_2202
Effects of PIP2 hydrolysis pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.487498 Hs.641066
RefSeq NM_001142936 NM_139179
HUGO
OMIM
CCDS CCDS47536 CCDS5350
HPRD 17324
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca