Version 5.4
Homo sapiens Gene: AURKA
Summary
InnateDB Gene IDBG-81805.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AURKA
Gene Name aurora kinase A
Synonyms AIK; ARK1; AURA; AURORA2; BTAK; PPP1R47; STK15; STK6; STK7
Species Homo sapiens
Ensembl Gene ENSG00000087586
Encoded Proteins
IDBP-81807
aurora kinase A
IDBP-81809
aurora kinase A
IDBP-81811
aurora kinase A
IDBP-238565
aurora kinase A
IDBP-238567
aurora kinase A
IDBP-238569
aurora kinase A
IDBP-238571
aurora kinase A
IDBP-238575
aurora kinase A
IDBP-378970
aurora kinase A
IDBP-378972
aurora kinase A
IDBP-378976
aurora kinase A
IDBP-378979
aurora kinase A
IDBP-378981
aurora kinase A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:56369389-56392337
Strand Reverse strand
Band q13.2
Transcripts
ENST00000347343 ENSP00000216911
ENST00000371356 ENSP00000360407
ENST00000312783 ENSP00000321591
ENST00000395915 ENSP00000379251
ENST00000395914 ENSP00000379250
ENST00000395913 ENSP00000379249
ENST00000395911 ENSP00000379247
ENST00000395907 ENSP00000379243
ENST00000441357 ENSP00000393452
ENST00000420474 ENSP00000388073
ENST00000422322 ENSP00000405042
ENST00000456249 ENSP00000405170
ENST00000451915 ENSP00000401358
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 244 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 244 [view]
Protein-Protein 239 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 4 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0035174 histone serine kinase activity
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000212 meiotic spindle organization
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007051 spindle organization
GO:0007052 mitotic spindle organization
GO:0007057 spindle assembly involved in female meiosis I
GO:0007067 mitotic nuclear division
GO:0007100 mitotic centrosome separation
GO:0007126 meiotic nuclear division
GO:0009948 anterior/posterior axis specification
GO:0030030 cell projection organization
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031647 regulation of protein stability
GO:0032091 negative regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035404 histone-serine phosphorylation
GO:0043066 negative regulation of apoptotic process
GO:0043146 spindle stabilization
GO:0045840 positive regulation of mitosis
GO:0046605 regulation of centrosome cycle
GO:0046777 protein autophosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051297 centrosome organization
GO:0051642 centrosome localization
GO:0071539 protein localization to centrosome
GO:0090233 negative regulation of spindle checkpoint
GO:1900195 positive regulation of oocyte maturation
GO:1990138 neuron projection extension
Cellular Component
GO:0005634 nucleus
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005829 cytosol
GO:0005876 spindle microtubule
GO:0015630 microtubule cytoskeleton
GO:0030496 midbody
GO:0031616 spindle pole centrosome
GO:0042585 germinal vesicle
GO:0043203 axon hillock
GO:0045120 pronucleus
GO:0048471 perinuclear region of cytoplasm
GO:0072686 mitotic spindle
GO:0072687 meiotic spindle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027496
View Gene Order
ENSBTAG00000013009
Not yet available
Pathways
NETPATH
REACTOME
REACT_6761
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_115566
Cell Cycle pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
KEGG
hsa04114
Oocyte meiosis pathway
INOH
PID NCI
aurora_a_pathway
Aurora A signaling
ilk_pathway
Integrin-linked kinase signaling
aurora_b_pathway
Aurora B signaling
plk1_pathway
PLK1 signaling events
aurora_kinase_pathway
Signaling by Aurora kinases
Cross-References
SwissProt O14965
TrEMBL A3KFJ0 A3KFJ1 A3KFJ2 Q5QPD1 Q5QPD2 Q5QPD4
UniProt Splice Variant
Entrez Gene 6790
UniGene Hs.250822 Hs.608070
RefSeq NM_003600 NM_198433 NM_198434 NM_198435 NM_198436 NM_198437 XM_005260534 XM_006723871 XM_006723872
HUGO HGNC:11393
OMIM 603072
CCDS CCDS13451
HPRD
IMGT
EMBL AF008551 AF011467 AF011468 AF195942 AF195943 AF195944 AF195945 AF195946 AF195947 AL121914 BC001280 BC002499 BC006423 BC027464 CH471077 D84212
GenPept AAC12708 AAC23448 AAC63902 AAF29508 AAH01280 AAH02499 AAH06423 AAH27464 BAA23592 CAC12717 EAW75550 EAW75551 EAW75552 EAW75553 EAW75554 EAW75555 EAW75556 EAW75557 EAW75558 EAW75559 EAW75561 EAW75562
RNA Seq Atlas 6790

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca