Homo sapiens Gene: RGS3
Summary
InnateDB Gene IDBG-81812.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS3
Gene Name regulator of G-protein signaling 3
Synonyms C2PA; RGP3
Species Homo sapiens
Ensembl Gene ENSG00000138835
Encoded Proteins
regulator of G-protein signaling 3
regulator of G-protein signaling 3
regulator of G-protein signaling 3
regulator of G-protein signaling 3
regulator of G-protein signaling 3
regulator of G-protein signaling 3
regulator of G-protein signaling 3
regulator of G-protein signaling 3
regulator of G-protein signaling 3
regulator of G-protein signaling 3
regulator of G-protein signaling 3
regulator of G-protein signaling 3
regulator of G-protein signaling 3
regulator of G-protein signaling 3
regulator of G-protein signaling 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:113444731-113597743
Strand Forward strand
Band q32
Transcripts
ENST00000350696 ENSP00000259406
ENST00000342620 ENSP00000343359
ENST00000374140 ENSP00000363255
ENST00000317613 ENSP00000312844
ENST00000343817 ENSP00000340284
ENST00000374136 ENSP00000363251
ENST00000374134 ENSP00000363249
ENST00000394646 ENSP00000378141
ENST00000478599
ENST00000466735
ENST00000488259
ENST00000466314
ENST00000464306
ENST00000496113 ENSP00000418898
ENST00000460000
ENST00000470775
ENST00000496264
ENST00000462143 ENSP00000420356
ENST00000492676
ENST00000489082
ENST00000463806
ENST00000496275
ENST00000488620
ENST00000485822
ENST00000471324 ENSP00000417866
ENST00000487344
ENST00000467805 ENSP00000417994
ENST00000462403 ENSP00000436168
ENST00000497435
ENST00000490241
ENST00000620489 ENSP00000479017
ENST00000613049 ENSP00000482612
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 25 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Axon guidance pathway
INOH
GPCR signaling pathway
PID NCI
Ephrin B reverse signaling
Cross-References
SwissProt
TrEMBL C9J6G2
UniProt Splice Variant
Entrez Gene 5998
UniGene Hs.494875 Hs.693972
RefSeq NM_001276260 NM_001276261 NM_001276262 NM_001282922 NM_001282923 NM_017790 NM_130795 NM_134427 NM_144488 NM_144489 XM_006717219 XM_006717220 XM_006717221 XM_006717222 XM_006717223 XM_006717225 XM_006717229 XM_006717230
HUGO HGNC:9999
OMIM 602189
CCDS CCDS35113 CCDS35114 CCDS43869 CCDS65111 CCDS6797 CCDS6798
HPRD 03720
IMGT
EMBL AL137066 AL162727 AL359455
GenPept
RNA Seq Atlas 5998