Version 5.4
Homo sapiens Gene: AMBP
Summary
InnateDB Gene IDBG-81952.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AMBP
Gene Name alpha-1-microglobulin/bikunin precursor
Synonyms A1M; EDC1; HCP; HI30; IATIL; ITI; ITIL; ITILC; UTI
Species Homo sapiens
Ensembl Gene ENSG00000106927
Encoded Proteins
IDBP-81954
alpha-1-microglobulin/bikunin precursor
IDBP-809184
alpha-1-microglobulin/bikunin precursor
IDBP-809186
alpha-1-microglobulin/bikunin precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:114060127-114078472
Strand Reverse strand
Band q32
Transcripts
ENST00000265132 ENSP00000265132
ENST00000466610 ENSP00000475149
ENST00000540645
ENST00000603230 ENSP00000474859
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 18 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0019855 calcium channel inhibitor activity
GO:0019862 IgA binding
GO:0020037 heme binding
GO:0036094 small molecule binding
GO:0042803 protein homodimerization activity
GO:0046904 calcium oxalate binding
Biological Process
GO:0007155 cell adhesion
GO:0007565 female pregnancy
GO:0010951 negative regulation of endopeptidase activity
GO:0016032 viral process
GO:0018298 protein-chromophore linkage
GO:0030163 protein catabolic process
GO:0042167 heme catabolic process
GO:0046329 negative regulation of JNK cascade
GO:0050777 negative regulation of immune response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028356
View Gene Order
ENSBTAG00000015676
Not yet available
Pathways
NETPATH
REACTOME
REACT_160163
Scavenging of heme from plasma pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.436911
RefSeq NM_001633
HUGO
OMIM
CCDS CCDS6800
HPRD 01467
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca