Version 5.4
Homo sapiens Gene: BMP7
Summary
InnateDB Gene IDBG-82028.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BMP7
Gene Name bone morphogenetic protein 7
Synonyms OP-1
Species Homo sapiens
Ensembl Gene ENSG00000101144
Encoded Proteins
IDBP-238705
bone morphogenetic protein 7
IDBP-238707
bone morphogenetic protein 7
IDBP-379141
bone morphogenetic protein 7
IDBP-379142
bone morphogenetic protein 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:57168748-57266629
Strand Reverse strand
Band q13.31
Transcripts
ENST00000395864 ENSP00000379205
ENST00000395863 ENSP00000379204
ENST00000450594 ENSP00000398687
ENST00000433911 ENSP00000390814
ENST00000476877
ENST00000460817
ENST00000463939
ENST00000524700
ENST00000530870
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 28 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
Biological Process
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001654 eye development
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001707 mesoderm formation
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001837 epithelial to mesenchymal transition
GO:0007389 pattern specification process
GO:0007411 axon guidance
GO:0007435 salivary gland morphogenesis
GO:0008285 negative regulation of cell proliferation
GO:0009880 embryonic pattern specification
GO:0009887 organ morphogenesis
GO:0010664 negative regulation of striated muscle cell apoptotic process
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010942 positive regulation of cell death
GO:0016358 dendrite development
GO:0030198 extracellular matrix organization
GO:0030326 embryonic limb morphogenesis
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030855 epithelial cell differentiation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032355 response to estradiol
GO:0033280 response to vitamin D
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0034504 protein localization to nucleus
GO:0035239 tube morphogenesis
GO:0040007 growth
GO:0042325 regulation of phosphorylation
GO:0042326 negative regulation of phosphorylation
GO:0042347 negative regulation of NF-kappaB import into nucleus
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043065 positive regulation of apoptotic process
GO:0043401 steroid hormone mediated signaling pathway
GO:0043407 negative regulation of MAP kinase activity
GO:0043434 response to peptide hormone
GO:0045597 positive regulation of cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0045786 negative regulation of cell cycle
GO:0045839 negative regulation of mitosis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048468 cell development
GO:0048593 camera-type eye morphogenesis
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048762 mesenchymal cell differentiation
GO:0048812 neuron projection morphogenesis
GO:0050768 negative regulation of neurogenesis
GO:0051216 cartilage development
GO:0060272 embryonic skeletal joint morphogenesis
GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060485 mesenchyme development
GO:0060548 negative regulation of cell death
GO:0060686 negative regulation of prostatic bud formation
GO:0060687 regulation of branching involved in prostate gland morphogenesis
GO:0070487 monocyte aggregation
GO:0071456 cellular response to hypoxia
GO:0072040 negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
GO:0072125 negative regulation of glomerular mesangial cell proliferation
GO:0072133 metanephric mesenchyme morphogenesis
GO:0072134 nephrogenic mesenchyme morphogenesis
GO:0072136 metanephric mesenchymal cell proliferation involved in metanephros development
GO:1900006 positive regulation of dendrite development
GO:1900106 positive regulation of hyaluranon cable assembly
GO:2000121 regulation of removal of superoxide radicals
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0031988 membrane-bounded vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000008999
View Gene Order
ENSBTAG00000015362
Not yet available
Pathways
NETPATH
REACTOME
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_118779
Extracellular matrix organization pathway
KEGG
hsa04350
TGF-beta signaling pathway pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
INOH website
GPCR signaling pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
alk2pathway
ALK2 signaling events
bmppathway
BMP receptor signaling
Cross-References
SwissProt
TrEMBL B1AL00 Q9H2W7 Q9NQQ8
UniProt Splice Variant
Entrez Gene 655
UniGene Hs.473163 Hs.597967
RefSeq NM_001719
HUGO HGNC:1074
OMIM 112267
CCDS CCDS13455
HPRD 00212
IMGT
EMBL AF210054 AF289090 AL122058 AL157414
GenPept AAF97256 AAG43508
RNA Seq Atlas 655

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca