InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PPM1A

Summary

InnateDB Gene

IDBG-8210.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPM1A

Gene Name

protein phosphatase, Mg2+/Mn2+ dependent, 1A

Synonyms

PP2C-ALPHA; PP2CA; PP2Calpha

Species

Homo sapiens

Ensembl Gene

ENSG00000100614

Encoded Proteins

IDBP-8212

protein phosphatase, Mg2+/Mn2+ dependent, 1A

IDBP-8214

protein phosphatase, Mg2+/Mn2+ dependent, 1A

IDBP-240283

protein phosphatase, Mg2+/Mn2+ dependent, 1A

IDBP-601793

protein phosphatase, Mg2+/Mn2+ dependent, 1A

IDBP-603019

protein phosphatase, Mg2+/Mn2+ dependent, 1A

IDBP-598002

protein phosphatase, Mg2+/Mn2+ dependent, 1A

IDBP-591590

protein phosphatase, Mg2+/Mn2+ dependent, 1A

IDBP-589382

protein phosphatase, Mg2+/Mn2+ dependent, 1A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:60245752-60299087

Strand

Forward strand

Band

q23.1

Transcripts

ENST00000325642	ENSP00000327255
ENST00000325658	ENSP00000314850
ENST00000395076	ENSP00000378514
ENST00000531143	ENSP00000437200
ENST00000532036	ENSP00000436445
ENST00000528241	ENSP00000431453
ENST00000525399	ENSP00000435398
ENST00000531937	ENSP00000435575

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0030145	manganese ion binding
GO:0033192	calmodulin-dependent protein phosphatase activity
GO:0046872	metal ion binding
GO:0070412	R-SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006470	protein dephosphorylation
GO:0006499	N-terminal protein myristoylation
GO:0007050	cell cycle arrest
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008152	metabolic process
GO:0008286	insulin receptor signaling pathway
GO:0010467	gene expression
GO:0010991	negative regulation of SMAD protein complex assembly
GO:0016055	Wnt signaling pathway
GO:0016311	dephosphorylation
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0035970	peptidyl-threonine dephosphorylation
GO:0042347	negative regulation of NF-kappaB import into nucleus
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045893	positive regulation of transcription, DNA-templated