Homo sapiens Gene: HTR7
Summary
InnateDB Gene IDBG-82120.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HTR7
Gene Name 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Synonyms 5-HT7
Species Homo sapiens
Ensembl Gene ENSG00000148680
Encoded Proteins
5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:90740823-90857698
Strand Reverse strand
Band q23.31
Transcripts
ENST00000336152 ENSP00000337949
ENST00000371719 ENSP00000360784
ENST00000277874 ENSP00000277874
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004993 serotonin receptor activity
Biological Process
GO:0006939 smooth muscle contraction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007210 serotonin receptor signaling pathway
GO:0007268 synaptic transmission
GO:0007623 circadian rhythm
GO:0008015 blood circulation
GO:0042310 vasoconstriction
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Serotonin receptors pathway
Amine ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
Neuroactive ligand-receptor interaction pathway
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt P34969
TrEMBL
UniProt Splice Variant
Entrez Gene 3363
UniGene Hs.73739
RefSeq NM_000872 NM_019859 NM_019860
HUGO HGNC:5302
OMIM 182137
CCDS CCDS7409 CCDS7408 CCDS7410
HPRD 01639
IMGT
EMBL AB451482 AK292606 AL360011 AY493988 BC047526 CH471066 L21195 U68487 U68488 U68492 U68493
GenPept AAB48393 AAB48394 AAB48397 AAC37538 AAF07217 AAF07218 AAH47526 AAR87480 BAF85295 BAG70296 CAH69966 CAH69967 CAH69968 EAW50118 EAW50119 EAW50120
RNA Seq Atlas 3363