InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAE1

Summary

InnateDB Gene

IDBG-82129.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAE1

Gene Name

RAE1 RNA export 1 homolog (S. pombe)

Synonyms

dJ481F12.3; dJ800J21.1; MIG14; Mnrp41; MRNP41

Species

Homo sapiens

Ensembl Gene

ENSG00000101146

Encoded Proteins

IDBP-82131

RAE1 RNA export 1 homolog (S. pombe)

IDBP-238723

RAE1 RNA export 1 homolog (S. pombe)

IDBP-238725

RAE1 RNA export 1 homolog (S. pombe)

IDBP-379187

RAE1 RNA export 1 homolog (S. pombe)

IDBP-379188

RAE1 RNA export 1 homolog (S. pombe)

IDBP-379189

RAE1 RNA export 1 homolog (S. pombe)

IDBP-584736

RAE1 RNA export 1 homolog (S. pombe)

IDBP-591578

RAE1 RNA export 1 homolog (S. pombe)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:57351010-57379211

Strand

Forward strand

Band

q13.31

Transcripts

ENST00000371242	ENSP00000360286
ENST00000395841	ENSP00000379182
ENST00000395840	ENSP00000379181
ENST00000411894	ENSP00000392097
ENST00000429339	ENSP00000393264
ENST00000452119	ENSP00000402924
ENST00000492498	ENSP00000432698
ENST00000462438
ENST00000527947	ENSP00000432609

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.

Experimentally validated
Total	97 [view]
Protein-Protein	96 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008017	microtubule binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0005975	carbohydrate metabolic process
GO:0006406	mRNA export from nucleus
GO:0007077	mitotic nuclear envelope disassembly
GO:0008645	hexose transport
GO:0010827	regulation of glucose transport
GO:0015758	glucose transport
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport
GO:0071407	cellular response to organic cyclic compound

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005640	nuclear outer membrane
GO:0005643	nuclear pore
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton