Version 5.4
Homo sapiens Gene: SLC39A7
Summary
InnateDB Gene IDBG-82314.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC39A7
Gene Name solute carrier family 39 (zinc transporter), member 7
Synonyms D6S115E; D6S2244E; H2-KE4; HKE4; KE4; RING5; ZIP7
Species Homo sapiens
Ensembl Gene ENSG00000112473
Encoded Proteins
IDBP-82316
solute carrier family 39 (zinc transporter), member 7
IDBP-82318
solute carrier family 39 (zinc transporter), member 7
IDBP-375346
solute carrier family 39 (zinc transporter), member 7
IDBP-806905
solute carrier family 39 (zinc transporter), member 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2011]
The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:33200445-33204439
Strand Forward strand
Band p21.32
Transcripts
ENST00000374677 ENSP00000363809
ENST00000374675 ENSP00000363807
ENST00000444757 ENSP00000400978
ENST00000463972
ENST00000617885 ENSP00000478192
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 11 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006829 zinc ion transport
GO:0030001 metal ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024327
View Gene Order
ENSBTAG00000008191
Not yet available
Pathways
NETPATH
REACTOME
REACT_20603
Zinc influx into cells by the SLC39 gene family pathway
REACT_20547
Metal ion SLC transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_20530
Zinc transporters pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001077516 NM_001288777 NM_006979
HUGO
OMIM
CCDS CCDS43453
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca