InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TNFSF8

Summary

InnateDB Gene

IDBG-82328.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFSF8

Gene Name

tumor necrosis factor (ligand) superfamily, member 8

Synonyms

CD153; CD30L; CD30LG

Species

Homo sapiens

Ensembl Gene

ENSG00000106952

Encoded Proteins

IDBP-82330

tumor necrosis factor (ligand) superfamily, member 8

IDBP-808929

tumor necrosis factor (ligand) superfamily, member 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin\'s and some non-Hodgkin\'s lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:114893343-114930595

Strand

Reverse strand

Band

q33.1

Transcripts

ENST00000223795	ENSP00000223795
ENST00000474301
ENST00000618336	ENSP00000484651

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0008283	cell proliferation
GO:0043374	CD8-positive, alpha-beta T cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050830	defense response to Gram-positive bacterium

Cellular Component

GO:0005615	extracellular space
GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028362

View Gene Order

ENSBTAG00000025782

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001244 NM_001252290 XM_006717325

HUGO

OMIM

CCDS

CCDS6810 CCDS75884

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas