InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CUL3

Summary

InnateDB Gene

IDBG-82331.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CUL3

Gene Name

cullin 3

Synonyms

CUL-3; PHA2E

Species

Homo sapiens

Ensembl Gene

ENSG00000036257

Encoded Proteins

IDBP-82333

cullin 3

IDBP-82335

cullin 3

IDBP-292974

cullin 3

IDBP-292969

cullin 3

IDBP-389145

cullin 3

IDBP-389146

cullin 3

IDBP-389147

cullin 3

IDBP-812818

cullin 3

IDBP-812819

cullin 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:224470150-224585397

Strand

Reverse strand

Band

q36.2

Transcripts

ENST00000264414	ENSP00000264414
ENST00000344951	ENSP00000343601
ENST00000409096	ENSP00000387200
ENST00000409777	ENSP00000386525
ENST00000454323	ENSP00000400558
ENST00000451538	ENSP00000410575
ENST00000436172	ENSP00000400935
ENST00000432260	ENSP00000484410
ENST00000497715
ENST00000487558
ENST00000481135
ENST00000484081
ENST00000536702
ENST00000541548
ENST00000546102
ENST00000617432	ENSP00000477851

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1215 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	1215 [view]
Protein-Protein	1215 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0030332	cyclin binding
GO:0031208	POZ domain binding
GO:0031625	ubiquitin protein ligase binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000090	mitotic anaphase
GO:0000209	protein polyubiquitination
GO:0000902	cell morphogenesis
GO:0000910	cytokinesis
GO:0001701	in utero embryonic development
GO:0001831	trophectodermal cellular morphogenesis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006513	protein monoubiquitination
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0007050	cell cycle arrest
GO:0007229	integrin-mediated signaling pathway
GO:0007369	gastrulation
GO:0008054	cyclin catabolic process
GO:0008284	positive regulation of cell proliferation
GO:0016055	Wnt signaling pathway
GO:0016477	cell migration
GO:0016567	protein ubiquitination
GO:0017145	stem cell division
GO:0032467	positive regulation of cytokinesis
GO:0035024	negative regulation of Rho protein signal transduction
GO:0040016	embryonic cleavage
GO:0043149	stress fiber assembly
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0048208	COPII vesicle coating
GO:0051322	anaphase
GO:0097193	intrinsic apoptotic signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0005827	polar microtubule
GO:0016020	membrane
GO:0031461	cullin-RING ubiquitin ligase complex
GO:0031463	Cul3-RING ubiquitin ligase complex
GO:0070062	extracellular vesicular exosome