Version 5.4
Homo sapiens Gene: MSLN
Summary
InnateDB Gene IDBG-8270.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSLN
Gene Name mesothelin
Synonyms MPF; SMRP
Species Homo sapiens
Ensembl Gene ENSG00000102854
Encoded Proteins
IDBP-8272
mesothelin
IDBP-597702
mesothelin
IDBP-748596
IDBP-749842
IDBP-753564
IDBP-752927
IDBP-750093
IDBP-753836
IDBP-807872
mesothelin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:643262-768865
Strand Forward strand
Band p13.3
Transcripts
ENST00000382862 ENSP00000372313
ENST00000545450 ENSP00000442965
ENST00000563941 ENSP00000456008
ENST00000569566 ENSP00000458003
ENST00000561896 ENSP00000457847
ENST00000566269 ENSP00000454295
ENST00000563651 ENSP00000456132
ENST00000566549 ENSP00000456702
ENST00000620831 ENSP00000482893
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0031016 pancreas development
Cellular Component
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0031225 anchored component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000063011
View Gene Order
ENSBTAG00000000177
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.408488
RefSeq NM_001177355 NM_005823 NM_013404 XM_005255034 XM_006720836 XM_006720837
HUGO
OMIM
CCDS CCDS32356 CCDS45370
HPRD 03030
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca