Version 5.4
Homo sapiens Gene: RBP4
Summary
InnateDB Gene IDBG-82806.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBP4
Gene Name retinol binding protein 4, plasma
Synonyms RDCCAS
Species Homo sapiens
Ensembl Gene ENSG00000138207
Encoded Proteins
IDBP-82808
retinol binding protein 4, plasma
IDBP-82810
retinol binding protein 4, plasma
IDBP-82812
retinol binding protein 4, plasma
IDBP-811342
retinol binding protein 4, plasma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:93591687-93601744
Strand Reverse strand
Band q23.33
Transcripts
ENST00000371469 ENSP00000360524
ENST00000371467 ENSP00000360522
ENST00000371464 ENSP00000360519
ENST00000615669 ENSP00000480654
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005501 retinoid binding
GO:0005515 protein binding
GO:0016918 retinal binding
GO:0019841 retinol binding
GO:0034632 retinol transporter activity
GO:0036094 small molecule binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001523 retinoid metabolic process
GO:0001654 eye development
GO:0006094 gluconeogenesis
GO:0006810 transport
GO:0007283 spermatogenesis
GO:0007507 heart development
GO:0007603 phototransduction, visible light
GO:0008584 male gonad development
GO:0030277 maintenance of gastrointestinal epithelium
GO:0030324 lung development
GO:0032024 positive regulation of insulin secretion
GO:0032526 response to retinoic acid
GO:0032868 response to insulin
GO:0034633 retinol transport
GO:0042572 retinol metabolic process
GO:0042574 retinal metabolic process
GO:0042593 glucose homeostasis
GO:0045471 response to ethanol
GO:0048562 embryonic organ morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048738 cardiac muscle tissue development
GO:0048807 female genitalia morphogenesis
GO:0050908 detection of light stimulus involved in visual perception
GO:0051024 positive regulation of immunoglobulin secretion
GO:0060041 retina development in camera-type eye
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060059 embryonic retina morphogenesis in camera-type eye
GO:0060065 uterus development
GO:0060068 vagina development
GO:0060157 urinary bladder development
GO:0060347 heart trabecula formation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024990
View Gene Order
ENSBTAG00000000442
Not yet available
Pathways
NETPATH
REACTOME
REACT_160156
The canonical retinoid cycle in rods (twilight vision) pathway
REACT_24968
Retinoid metabolism and transport pathway
REACT_160130
Retinoid cycle disease events pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_006744
HUGO
OMIM
CCDS CCDS31249
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca