InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDK5RAP2

Summary

InnateDB Gene

IDBG-82889.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDK5RAP2

Gene Name

CDK5 regulatory subunit associated protein 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000136861

Encoded Proteins

IDBP-82893

CDK5 regulatory subunit associated protein 2

IDBP-82895

CDK5 regulatory subunit associated protein 2

IDBP-82899

CDK5 regulatory subunit associated protein 2

IDBP-379130

CDK5 regulatory subunit associated protein 2

IDBP-379133

CDK5 regulatory subunit associated protein 2

IDBP-473413

CDK5 regulatory subunit associated protein 2

IDBP-482974

CDK5 regulatory subunit associated protein 2

IDBP-478029

CDK5 regulatory subunit associated protein 2

IDBP-482717

CDK5 regulatory subunit associated protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:120388869-120580170

Strand

Reverse strand

Band

q33.2

Transcripts

ENST00000349780	ENSP00000343818
ENST00000360822	ENSP00000354065
ENST00000360190	ENSP00000353317
ENST00000433194
ENST00000416449	ENSP00000400395
ENST00000425647	ENSP00000409941
ENST00000495406
ENST00000480112	ENSP00000418418
ENST00000474262
ENST00000473282	ENSP00000419265
ENST00000484546
ENST00000480467
ENST00000483412
ENST00000468989
ENST00000479584
ENST00000482047	ENSP00000419640
ENST00000472883
ENST00000481266	ENSP00000417925
ENST00000491334

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.

Experimentally validated
Total	40 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008017	microtubule binding
GO:0015631	tubulin binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000132	establishment of mitotic spindle orientation
GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0001578	microtubule bundle formation
GO:0007059	chromosome segregation
GO:0007420	brain development
GO:0022008	neurogenesis
GO:0045664	regulation of neuron differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046600	negative regulation of centriole replication
GO:0051297	centrosome organization
GO:0090231	regulation of spindle checkpoint

Cellular Component

GO:0000242	pericentriolar material
GO:0000922	spindle pole
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0030054	cell junction
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome