Version 5.4
Homo sapiens Gene: MSR1
Summary
InnateDB Gene IDBG-8289.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSR1
Gene Name macrophage scavenger receptor 1
Synonyms CD204; phSR1; phSR2; SCARA1; SR-A; SRA
Species Homo sapiens
Ensembl Gene ENSG00000038945
Encoded Proteins
IDBP-8291
macrophage scavenger receptor 1
IDBP-8295
macrophage scavenger receptor 1
IDBP-8297
macrophage scavenger receptor 1
IDBP-8299
macrophage scavenger receptor 1
IDBP-361441
macrophage scavenger receptor 1
IDBP-483452
macrophage scavenger receptor 1
IDBP-476327
macrophage scavenger receptor 1
IDBP-484059
macrophage scavenger receptor 1
IDBP-484907
macrophage scavenger receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19914718
MSR1 is required for sensing human cytomegalovirus (HCMV) by endosomal TLR3 and TLR9 in monocytic THP-1 cells.
PMID 20162551
MRS1 (SR-A) is upregulated in TLR4-mediated LPS responses and these receptors contribute to the efficient capturing and clearance of invading microbial pathogens.
PMID 21460221
MSR1 deficiency leads to greater sensitivity to LPS-induced endotoxic shock. MSR1 down-regulates inflammatory gene expression in dendritic cells by suppressing TLR4-mediated activation of NFKB.
PMID 21756882
MSR1, one of the principal receptors expressed on macrophages, suppresses macrophage activation by inhibiting the binding of lipopolysaccharide (LPS) to TLR4 in a competitive manner; thus playing a pivotal role in the regulation of the LPS-induced inflammatory response. (Demonstrated in murine model)
PMID 22751446
Deletion of MSR1 results in protection from septic shock and modulation of TLR4 signalling in peritoneal macrophages. (Demonstrated in mice)
PMID 24257313
MSR1 and Cd36 share several ligands and are involved in largely overlapping physiological and pathological processes, but they differ significantly in their effects on proinflammatory and immunoregulatory functions of macrophages.
InnateDB Annotation from Orthologs
Summary
PMID 21460221
[Mus musculus] Msr1 deficiency leads to greater sensitivity to LPS-induced endotoxic shock. Msr1 down-regulates inflammatory gene expression in dendritic cells by suppressing Tlr4-mediated activation of NFKB.
PMID 21756882
[Mus musculus] Msr1, one of the principal receptors expressed on macrophages, suppresses macrophage activation by inhibiting the binding of lipopolysaccharide (LPS) to Tlr4 in a competitive manner; thus playing a pivotal role in the regulation of the LPS-induced inflammatory response.
PMID 24035364
[Mus musculus] Autophagy regulates phagocytosis by modulating the expression of scavenger receptors, Marco and Msr1
Entrez Gene
Summary This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer\'s disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:16107878-16567490
Strand Reverse strand
Band p22
Transcripts
ENST00000262101 ENSP00000262101
ENST00000350896 ENSP00000262100
ENST00000355282 ENSP00000347430
ENST00000381998 ENSP00000371428
ENST00000445506 ENSP00000405453
ENST00000522672 ENSP00000430536
ENST00000519060 ENSP00000428865
ENST00000518960 ENSP00000427905
ENST00000518026 ENSP00000429498
ENST00000521876
ENST00000518343
ENST00000517522
ENST00000520846
ENST00000522130
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
GO:0030169 low-density lipoprotein particle binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006898 receptor-mediated endocytosis
GO:0007165 signal transduction
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010886 positive regulation of cholesterol storage
GO:0030301 cholesterol transport
GO:0034381 plasma lipoprotein particle clearance
GO:0042953 lipoprotein transport
GO:0045087 innate immune response (InnateDB)
GO:0071407 cellular response to organic cyclic compound
Cellular Component
GO:0005581 collagen trimer
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0030666 endocytic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0034362 low-density lipoprotein particle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025044
View Gene Order
ENSBTAG00000002885
Not yet available
Pathways
NETPATH
REACTOME
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_163699
Scavenging by Class A Receptors pathway
KEGG
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E5RFI4
UniProt Splice Variant
Entrez Gene 4481
UniGene Hs.604577 Hs.734231
RefSeq NM_002445 NM_138715 NM_138716
HUGO HGNC:7376
OMIM 153622
CCDS CCDS5995 CCDS5996 CCDS5997
HPRD 01092
IMGT
EMBL AC010785 AC023396 AC087360 AC091162 AC145059
GenPept
RNA Seq Atlas 4481

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca