Version 5.4
Homo sapiens Gene: SP100
Summary
InnateDB Gene IDBG-82951.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SP100
Gene Name SP100 nuclear antigen
Synonyms lysp100b
Species Homo sapiens
Ensembl Gene ENSG00000067066
Encoded Proteins
IDBP-82953
SP100 nuclear antigen
IDBP-82957
SP100 nuclear antigen
IDBP-292942
SP100 nuclear antigen
IDBP-292937
SP100 nuclear antigen
IDBP-292941
SP100 nuclear antigen
IDBP-292940
SP100 nuclear antigen
IDBP-389222
SP100 nuclear antigen
IDBP-389224
SP100 nuclear antigen
IDBP-389225
SP100 nuclear antigen
IDBP-389226
SP100 nuclear antigen
IDBP-389227
SP100 nuclear antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:230415942-230544090
Strand Forward strand
Band q37.1
Transcripts
ENST00000264052 ENSP00000264052
ENST00000340126 ENSP00000343023
ENST00000409112 ENSP00000386427
ENST00000409824 ENSP00000387311
ENST00000409341 ENSP00000386404
ENST00000409897 ENSP00000386998
ENST00000432979 ENSP00000391616
ENST00000427101 ENSP00000399389
ENST00000413284 ENSP00000400277
ENST00000452345 ENSP00000416563
ENST00000431952 ENSP00000393679
ENST00000470940
ENST00000466710
ENST00000462751
ENST00000494508
ENST00000492546
ENST00000459786
ENST00000494901
ENST00000488180
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
Experimentally validated
Total 56 [view]
Protein-Protein 54 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0019900 kinase binding
GO:0019904 protein domain specific binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0070087 chromo shadow domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000723 telomere maintenance
GO:0006351 transcription, DNA-templated
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0010596 negative regulation of endothelial cell migration
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0032526 response to retinoic acid
GO:0032897 negative regulation of viral transcription
GO:0034097 response to cytokine
GO:0034340 response to type I interferon
GO:0034341 response to interferon-gamma
GO:0043392 negative regulation of DNA binding
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045765 regulation of angiogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046826 negative regulation of protein export from nucleus
GO:0048384 retinoic acid receptor signaling pathway
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051271 negative regulation of cellular component movement
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902044 regulation of Fas signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016605 PML body
GO:0030870 Mre11 complex
GO:0034399 nuclear periphery
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_25078
Interferon gamma signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P23497
TrEMBL C9JBL0 E9PHV6 H7C4B4 Q4ZG64 Q53TD0
UniProt Splice Variant
Entrez Gene 6672
UniGene Hs.369056 Hs.603387
RefSeq NM_001080391 NM_001206701 NM_001206702 NM_001206703 NM_001206704 NM_003113
HUGO HGNC:11206
OMIM 604585
CCDS CCDS2477 CCDS42832 CCDS56170 CCDS56171 CCDS56172 CCDS56173
HPRD
IMGT
EMBL AC009949 AC010149 AF056322 AF076675 AF255565 AF378670 AK293373 BC011562 L79986 L79987 L79988 M60618 U36501 X95472
GenPept AAA35537 AAC39790 AAC50743 AAF39781 AAH11562 AAK51202 AAK57703 AAL77438 AAL77439 AAL77441 AAX88870 AAY14879 BAG56886 CAA64744
RNA Seq Atlas 6672

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca