Version 5.4
Homo sapiens Gene: TRAF1
Summary
InnateDB Gene IDBG-83153.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRAF1
Gene Name TNF receptor-associated factor 1
Synonyms EBI6; MGC:10353
Species Homo sapiens
Ensembl Gene ENSG00000056558
Encoded Proteins
IDBP-83155
TNF receptor-associated factor 1
IDBP-591936
TNF receptor-associated factor 1
IDBP-589503
TNF receptor-associated factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19698991
TRAF1 is a positive regulator of the NF-kappaB alternative pathway.
PMID 19540595
TRAF1 mediates both the CD30 signaling-dependent and independent NF-kappaB activation, which prevents lymphoma cells from spontaneous and induced apoptosis.
PMID 18429822
TRAF1 phosphorylation by the ubiquitously expressed kinase PKN1 plays a critical role in the negative regulation of tonic activity of JNK and NF-kappaB signalling pathways.
Entrez Gene
Summary The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:120902393-120929173
Strand Reverse strand
Band q33.2
Transcripts
ENST00000373887 ENSP00000362994
ENST00000540010 ENSP00000443183
ENST00000546084 ENSP00000438583
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 124 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 124 [view]
Protein-Protein 122 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0031625 ubiquitin protein ligase binding
GO:0031996 thioesterase binding
Biological Process
GO:0006461 protein complex assembly
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:2001236 regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026875
View Gene Order
ENSBTAG00000003012
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
NetPath_21
RANKL pathway
NetPath_26
TWEAK pathway
REACTOME
KEGG
hsa05222
Small cell lung cancer pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
cd40_pathway
CD40/CD40L signaling
tnfpathway
TNF receptor signaling pathway
hivnefpathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Cross-References
SwissProt Q13077
TrEMBL
UniProt Splice Variant
Entrez Gene 7185
UniGene Hs.531251
RefSeq NM_001190945 NM_001190947 NM_005658
HUGO HGNC:12031
OMIM 601711
CCDS CCDS55335 CCDS6825
HPRD
IMGT
EMBL AC006430 AK090468 AK295959 AK315476 AL832989 BC024145 BT019408 CH471090 U19261
GenPept AAA62309 AAH24145 AAV38215 BAC03449 BAG37860 BAG58739 CAH56343 EAW87479
RNA Seq Atlas 7185

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca