Homo sapiens Gene: CYP2C18 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-83204.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | CYP2C18 | ||||||||||||||||||
Gene Name | cytochrome P450, family 2, subfamily C, polypeptide 18 | ||||||||||||||||||
Synonyms | CPCI; CYP2C; CYP2C17; P450-6B/29C; P450IIC17 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000108242 | ||||||||||||||||||
Encoded Proteins |
cytochrome P450, family 2, subfamily C, polypeptide 18
cytochrome P450, family 2, subfamily C, polypeptide 18
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 10:94683621-94736190 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q23.33 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
No orthologs found for this gene | |||||||||||||||||||
Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Xenobiotics pathway
Cytochrome P450 - arranged by substrate type pathway
Metabolism pathway
Biological oxidations pathway
Phase 1 - Functionalization of compounds pathway
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KEGG |
Retinol metabolism pathway
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INOH |
Tryptophan degradation pathway
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PID NCI |
FOXA1 transcription factor network
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Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.511872 Hs.694505 | ||||||||||||||||||
RefSeq | NM_000772 NM_001128925 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS44460 CCDS7435 | ||||||||||||||||||
HPRD | 03085 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||