Version 5.4
Homo sapiens Gene: TH1L
Summary
InnateDB Gene IDBG-83212.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TH1L
Gene Name TH1-like (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101158
Encoded Proteins
IDBP-83214
TH1-like (Drosophila)
IDBP-597204
TH1-like (Drosophila)
IDBP-813719
negative elongation factor complex member C/D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:58981208-58995133
Strand Forward strand
Band q13.32
Transcripts
ENST00000344018 ENSP00000342300
ENST00000471621
ENST00000492016
ENST00000460601 ENSP00000436783
ENST00000482747
ENST00000464363
ENST00000477741
ENST00000474543
ENST00000478389
ENST00000497935
ENST00000490205
ENST00000479207
ENST00000486263
ENST00000602795 ENSP00000473290
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 47 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006366 transcription from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0010467 gene expression
GO:0016032 viral process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0050434 positive regulation of viral transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0032021 NELF complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000016253
View Gene Order
ENSBTAG00000018783
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_6344
Tat-mediated HIV elongation arrest and recovery pathway
REACT_6143
Pausing and recovery of Tat-mediated HIV elongation pathway
REACT_22107
RNA Polymerase II Pre-transcription Events pathway
REACT_1845
Formation of RNA Pol II elongation complex pathway
REACT_846
Formation of the Early Elongation Complex pathway
REACT_833
RNA Polymerase II Transcription Elongation pathway
REACT_22201
Formation of HIV elongation complex in the absence of HIV Tat pathway
REACT_6244
Pausing and recovery of HIV elongation pathway
REACT_6319
Formation of the HIV-1 Early Elongation Complex pathway
REACT_6346
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
REACT_6162
Tat-mediated elongation of the HIV-1 transcript pathway
REACT_6261
Abortive elongation of HIV-1 transcript in the absence of Tat pathway
REACT_6259
HIV elongation arrest and recovery pathway
REACT_6233
Transcription of the HIV genome pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_6274
HIV Transcription Elongation pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.517148 Hs.604639 Hs.629101
RefSeq NM_198976
HUGO
OMIM
CCDS CCDS13473
HPRD 16096
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca