Version 5.4
Homo sapiens Gene: ALPI
Summary
InnateDB Gene IDBG-83245.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALPI
Gene Name alkaline phosphatase, intestinal
Synonyms IAP
Species Homo sapiens
Ensembl Gene ENSG00000163295
Encoded Proteins
IDBP-83247
alkaline phosphatase, intestinal
IDBP-389299
alkaline phosphatase, intestinal
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is upregulated during small intestinal epithelial cell differentiation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:232456123-232460032
Strand Forward strand
Band q37.1
Transcripts
ENST00000295463 ENSP00000295463
ENST00000457560 ENSP00000413068
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0002020 protease binding
GO:0003824 catalytic activity
GO:0004035 alkaline phosphatase activity
GO:0008270 zinc ion binding
GO:0016791 phosphatase activity
Biological Process
GO:0008152 metabolic process
GO:0016311 dephosphorylation
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031225 anchored component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000079440
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa00790
Folate biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.37009
RefSeq NM_001631
HUGO
OMIM
CCDS CCDS2492
HPRD 01376
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca