Version 5.4
Homo sapiens Gene: NGEF
Summary
InnateDB Gene IDBG-83399.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NGEF
Gene Name neuronal guanine nucleotide exchange factor
Synonyms ARHGEF27; EPHEXIN
Species Homo sapiens
Ensembl Gene ENSG00000066248
Encoded Proteins
IDBP-83401
neuronal guanine nucleotide exchange factor
IDBP-83403
neuronal guanine nucleotide exchange factor
IDBP-292891
neuronal guanine nucleotide exchange factor
IDBP-389349
neuronal guanine nucleotide exchange factor
IDBP-389350
neuronal guanine nucleotide exchange factor
IDBP-389351
neuronal guanine nucleotide exchange factor
IDBP-389352
neuronal guanine nucleotide exchange factor
IDBP-389354
neuronal guanine nucleotide exchange factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:232878686-233013272
Strand Reverse strand
Band q37.1
Transcripts
ENST00000264051 ENSP00000264051
ENST00000373552 ENSP00000362653
ENST00000409079 ENSP00000387033
ENST00000424488 ENSP00000387591
ENST00000416114 ENSP00000401063
ENST00000458735 ENSP00000412614
ENST00000420650 ENSP00000407544
ENST00000414326 ENSP00000405053
ENST00000489127
ENST00000461944
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0009987 cellular process
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0043087 regulation of GTPase activity
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0061002 negative regulation of dendritic spine morphogenesis
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0030426 growth cone
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026259
View Gene Order
ENSBTAG00000008942
Not yet available
Pathways
NETPATH
REACTOME
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_18266
Axon guidance pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_228170
EPH-Ephrin signaling pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
epha_fwdpathway
EPHA forward signaling
rac1_reg_pathway
Regulation of RAC1 activity
rhoa_reg_pathway
Regulation of RhoA activity
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 25791
UniGene Hs.97316
RefSeq NM_001114090 NM_019850
HUGO HGNC:7807
OMIM 605991
CCDS CCDS2500 CCDS46544
HPRD 10442
IMGT
EMBL
GenPept
RNA Seq Atlas 25791

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca