Version 5.4
Homo sapiens Gene: TCTN3
Summary
InnateDB Gene IDBG-83525.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCTN3
Gene Name tectonic family member 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000119977
Encoded Proteins
IDBP-83527
tectonic family member 3
IDBP-83531
tectonic family member 3
IDBP-83533
tectonic family member 3
IDBP-383357
tectonic family member 3
IDBP-813775
tectonic family member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the tectonic gene family which functions in Hedgehog signal transduction and development of the neural tube. Mutations in this gene have been associated with Orofaciodigital Syndrome IV and Joubert Syndrom 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:95663396-95694143
Strand Reverse strand
Band q24.1
Transcripts
ENST00000371217 ENSP00000360261
ENST00000265993 ENSP00000265993
ENST00000371209 ENSP00000360253
ENST00000430368 ENSP00000387567
ENST00000497399
ENST00000478245
ENST00000614499 ENSP00000483364
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0007224 smoothened signaling pathway
GO:0060271 cilium morphogenesis
Cellular Component
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025008
View Gene Order
ENSBTAG00000011841
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.438991 Hs.596998
RefSeq NM_001143973 NM_015631
HUGO
OMIM
CCDS CCDS31258 CCDS44461
HPRD 12582
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca