Version 5.4
Homo sapiens Gene: SLC25A5
Summary
InnateDB Gene IDBG-83661.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC25A5
Gene Name solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
Synonyms 2F1; AAC2; ANT2; T2; T3
Species Homo sapiens
Ensembl Gene ENSG00000005022
Encoded Proteins
IDBP-83663
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Sep 2009]
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome X:119468400-119471319
Strand Forward strand
Band q24
Transcripts
ENST00000317881 ENSP00000360671
ENST00000475354
ENST00000460013
ENST00000463551
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 120 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 120 [view]
Protein-Protein 119 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015207 adenine transmembrane transporter activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0006810 transport
GO:0007059 chromosome segregation
GO:0008284 positive regulation of cell proliferation
GO:0015853 adenine transport
GO:0016032 viral process
GO:0044281 small molecule metabolic process
GO:0050796 regulation of insulin secretion
GO:0055085 transmembrane transport
GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0042645 mitochondrial nucleoid
GO:0070062 extracellular vesicular exosome
GO:0071817 MMXD complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000016319
View Gene Order
ENSBTAG00000046037
Not yet available
Pathways
NETPATH
REACTOME
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_8016
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization pathway
REACT_6757
Interactions of Vpr with host cellular proteins pathway
REACT_6185
HIV Infection pathway
REACT_111217
Metabolism pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_116125
Disease pathway
KEGG
hsa04020
Calcium signaling pathway pathway
hsa05012
Parkinson's disease pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.487903 Hs.693120 Hs.709497
RefSeq NM_001152
HUGO
OMIM
CCDS CCDS14578
HPRD 02147
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca