Version 5.4
Homo sapiens Gene: SEPT6
Summary
InnateDB Gene IDBG-83838.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEPT6
Gene Name septin 6
Synonyms SEP2; SEPT2
Species Homo sapiens
Ensembl Gene ENSG00000125354
Encoded Proteins
IDBP-83840
septin 6
IDBP-83842
septin 6
IDBP-83848
septin 6
IDBP-83850
septin 6
IDBP-241211
septin 6
IDBP-602256
septin 6
IDBP-481103
septin 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:119615724-119693370
Strand Reverse strand
Band q24
Transcripts
ENST00000360156 ENSP00000353278
ENST00000354228 ENSP00000346169
ENST00000354416 ENSP00000346397
ENST00000343984 ENSP00000341524
ENST00000394610 ENSP00000378108
ENST00000460411 ENSP00000435818
ENST00000489216 ENSP00000418715
ENST00000467310
ENST00000481072
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 23 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0000910 cytokinesis
GO:0007049 cell cycle
GO:0016032 viral process
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0005819 spindle
GO:0008021 synaptic vesicle
GO:0030496 midbody
GO:0031105 septin complex
GO:0032154 cleavage furrow
GO:0043679 axon terminus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050379
View Gene Order
ENSBTAG00000004291
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.496666 Hs.598119
RefSeq NM_015129 NM_145799 NM_145800 NM_145802 XM_005262400 XM_006724748 XM_006724749 XM_006724750
HUGO
OMIM
CCDS CCDS14583 CCDS14584 CCDS14585
HPRD 06716
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca