Homo sapiens Gene: ISG15 | |||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||
InnateDB Gene | IDBG-84312.6 | ||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
Gene Symbol | ISG15 | ||||||||||||||||||||||||||||
Gene Name | ISG15 ubiquitin-like modifier | ||||||||||||||||||||||||||||
Synonyms | G1P2; hUCRP; IFI15; IP17; UCRP | ||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000187608 | ||||||||||||||||||||||||||||
Encoded Proteins |
ISG15 ubiquitin-like modifier
ISG15 ubiquitin-like modifier
ISG15 ubiquitin-like modifier
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Protein Structure | |||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||
Summary |
ISG15 (ISGylation) post-translational modification is mediated by a sequential reaction similar to ubiquitination and has been shown to negatively regulate the NF-kappaB pathway.
ISG15 expression is induced during a hepatitis C virus infection in an IRF3-dependent manner. ISG15 acts as a negative modulator of the RIG-I pathway by mediating the level of DDX58 (RIG-I) ubiquitination.
ISG15 does not directly alter human rhinovirus replication but modulates immune signalling via the viral sensor protein DDX58 to impact production of CXCL10, which has been linked to innate immunity to viruses.
Human rhinovirus infection of epithelial cells induces the expression and secretion of ISG15, which modulates immune responses via effects on DDX58, and by regulating CXCL10 production.
ISG15 protects against Listeria monocytogenes infection.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||
Summary |
[Mus musculus] Isg15 expression is induced during a hepatitis C virus infection in an Irf3-dependent manner. Isg15 acts as a negative modulator of the RIG-I pathway by mediating the level of Ddx58 (RIG-I) ubiquitination. (Demonstrated in human)
[Mus musculus] Isg15 protects against Listeria monocytogenes infection.
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Entrez Gene | |||||||||||||||||||||||||||||
Summary |
The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012] |
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Gene Information | |||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||
Genomic Location | Chromosome 1:1001138-1014541 | ||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||
Band | p36.33 | ||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 244 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||
REACTOME |
Negative regulators of RIG-I/MDA5 signaling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Interferon alpha/beta signaling pathway
ISG15 antiviral mechanism pathway
Antiviral mechanism by IFN-stimulated genes pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Interferon Signaling pathway
Immune System pathway
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KEGG |
RIG-I-like receptor signaling pathway pathway
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INOH | |||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||
UniGene | |||||||||||||||||||||||||||||
RefSeq | NM_005101 | ||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||
CCDS | CCDS6 | ||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||