InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SRPK1

Summary

InnateDB Gene

IDBG-84414.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRPK1

Gene Name

SRSF protein kinase 1

Synonyms

SFRSK1

Species

Homo sapiens

Ensembl Gene

ENSG00000096063

Encoded Proteins

IDBP-84416

SRSF protein kinase 1

IDBP-84418

SRSF protein kinase 1

IDBP-84420

SRSF protein kinase 1

IDBP-376675

SRSF protein kinase 1

IDBP-478142

SRSF protein kinase 1

IDBP-480225

SRSF protein kinase 1

IDBP-484677

SRSF protein kinase 1

IDBP-484812

SRSF protein kinase 1

IDBP-478084

SRSF protein kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:35832966-35921342

Strand

Reverse strand

Band

p21.31

Transcripts

ENST00000361690	ENSP00000354674
ENST00000373825	ENSP00000362931
ENST00000373822	ENSP00000362928
ENST00000373821
ENST00000346162
ENST00000423325	ENSP00000391069
ENST00000505885
ENST00000507292	ENSP00000422886
ENST00000502969
ENST00000510290	ENSP00000424170
ENST00000508473	ENSP00000425172
ENST00000512445	ENSP00000424068
ENST00000513367
ENST00000507909	ENSP00000424323

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 372 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	372 [view]
Protein-Protein	372 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006397	mRNA processing
GO:0006468	protein phosphorylation
GO:0007059	chromosome segregation
GO:0008380	RNA splicing
GO:0016032	viral process
GO:0035092	sperm chromatin condensation
GO:0035556	intracellular signal transduction
GO:0045070	positive regulation of viral genome replication
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response
GO:0048024	regulation of mRNA splicing, via spliceosome
GO:0050684	regulation of mRNA processing

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0016363	nuclear matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000004865

View Gene Order

ENSBTAG00000016838

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.443861 Hs.611831

RefSeq

NM_003137

HUGO

OMIM

CCDS

CCDS47415

HPRD

15992

IMGT

EMBL

GenPept

RNA Seq Atlas