Version 5.4
Homo sapiens Gene: LAMA5
Summary
InnateDB Gene IDBG-84449.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LAMA5
Gene Name laminin, alpha 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000130702
Encoded Proteins
IDBP-84453
laminin, alpha 5
IDBP-480794
laminin, alpha 5
IDBP-811373
laminin, alpha 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:62307955-62367312
Strand Reverse strand
Band q13.33
Transcripts
ENST00000252999 ENSP00000252999
ENST00000370691
ENST00000370677
ENST00000492698
ENST00000495695
ENST00000462415
ENST00000491036
ENST00000468786
ENST00000471042
ENST00000481120
ENST00000464134
ENST00000497363
ENST00000474128 ENSP00000420069
ENST00000497053 ENSP00000481814
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005178 integrin binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001738 morphogenesis of a polarized epithelium
GO:0001755 neural crest cell migration
GO:0001942 hair follicle development
GO:0007010 cytoskeleton organization
GO:0007155 cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007517 muscle organ development
GO:0008037 cell recognition
GO:0008283 cell proliferation
GO:0009790 embryo development
GO:0009887 organ morphogenesis
GO:0016331 morphogenesis of embryonic epithelium
GO:0016477 cell migration
GO:0022617 extracellular matrix disassembly
GO:0030154 cell differentiation
GO:0030155 regulation of cell adhesion
GO:0030198 extracellular matrix organization
GO:0030324 lung development
GO:0030334 regulation of cell migration
GO:0034446 substrate adhesion-dependent cell spreading
GO:0042127 regulation of cell proliferation
GO:0042384 cilium assembly
GO:0042475 odontogenesis of dentin-containing tooth
GO:0045446 endothelial cell differentiation
GO:0045995 regulation of embryonic development
GO:0048041 focal adhesion assembly
GO:0048754 branching morphogenesis of an epithelial tube
GO:0060445 branching involved in salivary gland morphogenesis
GO:0090002 establishment of protein localization to plasma membrane
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0005605 basal lamina
GO:0005606 laminin-1 complex
GO:0005610 laminin-5 complex
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0031012 extracellular matrix
GO:0043259 laminin-10 complex
GO:0043260 laminin-11 complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015647
View Gene Order
ENSBTAG00000003061
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
REACTOME
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_163906
ECM proteoglycans pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
REACT_169262
Laminin interactions pathway
KEGG
hsa04512
ECM-receptor interaction pathway
hsa05222
Small cell lung cancer pathway
hsa04510
Focal adhesion pathway
hsa05200
Pathways in cancer pathway
hsa05146
Amoebiasis pathway
hsa05145
Toxoplasmosis pathway
INOH
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
integrin4_pathway
Alpha6 beta4 integrin-ligand interactions
syndecan_1_pathway
Syndecan-1-mediated signaling events
Cross-References
SwissProt O15230
TrEMBL H7C5J6 O75079
UniProt Splice Variant
Entrez Gene 3911
UniGene Hs.473256
RefSeq NM_005560 XM_006723796 XM_006723797 XM_006723798
HUGO HGNC:6485
OMIM 601033
CCDS CCDS33502
HPRD
IMGT
EMBL AB010099 AB011105 AB067494 AF443072 AL354836 Z95636
GenPept AAM12527 BAA25459 BAA31347 BAB67800 CAB09137 CAC22310
RNA Seq Atlas 3911

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca