Version 5.4
Homo sapiens Gene: PER2
Summary
InnateDB Gene IDBG-84518.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PER2
Gene Name period homolog 2 (Drosophila)
Synonyms FASPS; FASPS1
Species Homo sapiens
Ensembl Gene ENSG00000132326
Encoded Proteins
IDBP-84520
period homolog 2 (Drosophila)
IDBP-84522
period homolog 2 (Drosophila)
IDBP-389542
period homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. [provided by RefSeq, Jul 2008]
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:238244038-238290102
Strand Reverse strand
Band q37.3
Transcripts
ENST00000355768 ENSP00000348013
ENST00000254657 ENSP00000254657
ENST00000431832 ENSP00000405891
ENST00000491417
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000989 transcription factor binding transcription factor activity
GO:0001222 transcription corepressor binding
GO:0003713 transcription coactivator activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019900 kinase binding
GO:0035257 nuclear hormone receptor binding
GO:0036002 pre-mRNA binding
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0070063 RNA polymerase binding
GO:1990226 histone methyltransferase binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002931 response to ischemia
GO:0005978 glycogen biosynthetic process
GO:0006094 gluconeogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006631 fatty acid metabolic process
GO:0007165 signal transduction
GO:0007623 circadian rhythm
GO:0019229 regulation of vasoconstriction
GO:0019249 lactate biosynthetic process
GO:0031397 negative regulation of protein ubiquitination
GO:0032922 circadian regulation of gene expression
GO:0042752 regulation of circadian rhythm
GO:0042754 negative regulation of circadian rhythm
GO:0045892 negative regulation of transcription, DNA-templated
GO:0050767 regulation of neurogenesis
GO:0050796 regulation of insulin secretion
GO:0050872 white fat cell differentiation
GO:0051726 regulation of cell cycle
GO:0051946 regulation of glutamate uptake involved in transmission of nerve impulse
GO:0060567 negative regulation of DNA-templated transcription, termination
GO:0070345 negative regulation of fat cell proliferation
GO:0070932 histone H3 deacetylation
GO:0097167 circadian regulation of translation
GO:2000678 negative regulation of transcription regulatory region DNA binding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000055866
View Gene Order
ENSBTAG00000045685
Not yet available
Pathways
NETPATH
REACTOME
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_24941
Circadian Clock pathway
KEGG
hsa04710
Circadian rhythm pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.58756 Hs.743533
RefSeq NM_022817 XM_005246111 XM_006712824
HUGO
OMIM
CCDS CCDS2528
HPRD 04575
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca