InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TP53BP1

Summary

InnateDB Gene

IDBG-8462.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TP53BP1

Gene Name

tumor protein p53 binding protein 1

Synonyms

53BP1; p202

Species

Homo sapiens

Ensembl Gene

ENSG00000067369

Encoded Proteins

IDBP-8464

tumor protein p53 binding protein 1

IDBP-8468

tumor protein p53 binding protein 1

IDBP-8470

tumor protein p53 binding protein 1

IDBP-369449

tumor protein p53 binding protein 1

IDBP-369456

tumor protein p53 binding protein 1

IDBP-369459

tumor protein p53 binding protein 1

IDBP-369462

tumor protein p53 binding protein 1

IDBP-369466

tumor protein p53 binding protein 1

IDBP-369469

tumor protein p53 binding protein 1

IDBP-744791

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:43403061-43510728

Strand

Reverse strand

Band

q15.3

Transcripts

ENST00000263801	ENSP00000263801
ENST00000382044	ENSP00000371475
ENST00000382039	ENSP00000371470
ENST00000450115	ENSP00000393497
ENST00000411772	ENSP00000413010
ENST00000434595	ENSP00000416212
ENST00000434561	ENSP00000392048
ENST00000417342	ENSP00000398508
ENST00000413546	ENSP00000388028
ENST00000414758
ENST00000476454
ENST00000467474	ENSP00000471624
ENST00000480860
ENST00000477089
ENST00000572085
ENST00000571145
ENST00000605155

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 162 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	162 [view]
Protein-Protein	160 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0002039	p53 binding
GO:0003684	damaged DNA binding
GO:0005515	protein binding
GO:0035064	methylated histone binding
GO:0042162	telomeric DNA binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006366	transcription from RNA polymerase II promoter
GO:0006974	cellular response to DNA damage stimulus
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000781	chromosome, telomeric region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005657	replication fork
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000043909

View Gene Order

ENSBTAG00000021304

Not yet available

Pathways

NETPATH

REACTOME

REACT_97

Recruitment of repair and signaling proteins to double-strand breaks pathway

REACT_1874

Homologous Recombination Repair pathway

REACT_2054

Double-Strand Break Repair pathway

REACT_1587

Homologous recombination repair of replication-independent double-strand breaks pathway

REACT_216

DNA Repair pathway

KEGG

INOH

PID NCI

atm_pathway

ATM pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.440968

RefSeq

NM_001141979 NM_001141980 NM_005657 XM_005254634 XM_005254635 XM_006720666

HUGO

OMIM

CCDS

CCDS10096 CCDS45250 CCDS45251

HPRD

05569

IMGT

EMBL

GenPept

RNA Seq Atlas