Version 5.4
Homo sapiens Gene: DENND1A
Summary
InnateDB Gene IDBG-84620.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DENND1A
Gene Name DENN/MADD domain containing 1A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000119522
Encoded Proteins
IDBP-84622
DENN/MADD domain containing 1A
IDBP-84626
DENN/MADD domain containing 1A
IDBP-84628
DENN/MADD domain containing 1A
IDBP-242011
DENN/MADD domain containing 1A
IDBP-242013
DENN/MADD domain containing 1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:123379654-123930152
Strand Reverse strand
Band q33.3
Transcripts
ENST00000373624 ENSP00000362727
ENST00000373620 ENSP00000362722
ENST00000373618 ENSP00000362720
ENST00000394219 ENSP00000377766
ENST00000394215 ENSP00000377763
ENST00000473039
ENST00000475421
ENST00000491650
ENST00000497135
ENST00000479305
ENST00000462245
ENST00000474676
ENST00000475615
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017112 Rab guanyl-nucleotide exchange factor activity
GO:0017124 SH3 domain binding
Biological Process
GO:0006897 endocytosis
GO:0015031 protein transport
GO:0032483 regulation of Rab protein signal transduction
GO:0032851 positive regulation of Rab GTPase activity
GO:0048488 synaptic vesicle endocytosis
Cellular Component
GO:0030054 cell junction
GO:0030136 clathrin-coated vesicle
GO:0030425 dendrite
GO:0030665 clathrin-coated vesicle membrane
GO:0042734 presynaptic membrane
GO:0043025 neuronal cell body
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035392
View Gene Order
ENSBTAG00000003610
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.568340 Hs.682912
RefSeq NM_020946 NM_024820 XM_005252111 XM_005252113
HUGO
OMIM
CCDS CCDS35133 CCDS35134
HPRD 17221
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca