InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PGAM1

Summary

InnateDB Gene

IDBG-84719.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGAM1

Gene Name

phosphoglycerate mutase 1 (brain)

Synonyms

HEL-S-35; PGAM-B; PGAMA

Species

Homo sapiens

Ensembl Gene

ENSG00000171314

Encoded Proteins

IDBP-84721

phosphoglycerate mutase 1 (brain)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Phosphoglyceric acid mutase (EC 2.7.5.3) is widely distributed in mammalian tissues where it catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway (summary by Chen et al., 1974 [PubMed 4811757]).[supplied by OMIM, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:97426160-97433441

Strand

Forward strand

Band

q24.1

Transcripts

ENST00000334828	ENSP00000359991
ENST00000473929
ENST00000467867

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004082	bisphosphoglycerate mutase activity
GO:0004083	bisphosphoglycerate 2-phosphatase activity
GO:0004619	phosphoglycerate mutase activity
GO:0005515	protein binding
GO:0016868	intramolecular transferase activity, phosphotransferases
GO:0019901	protein kinase binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0006110	regulation of glycolytic process
GO:0016311	dephosphorylation
GO:0043456	regulation of pentose-phosphate shunt
GO:0044281	small molecule metabolic process
GO:0045730	respiratory burst

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000011752

View Gene Order

ENSBTAG00000012697

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

NetPath_11

TCR pathway

REACTOME

REACT_1383

Glycolysis pathway

REACT_1520

Gluconeogenesis pathway

REACT_200783

Myoclonic epilepsy of Lafora pathway

REACT_474

Metabolism of carbohydrates pathway

REACT_111217

Metabolism pathway

REACT_116125

Disease pathway

REACT_723

Glucose metabolism pathway

REACT_200833

Glycogen storage diseases pathway

KEGG

hsa00010

Glycolysis / Gluconeogenesis pathway

hsa00260

Glycine, serine and threonine metabolism pathway

INOH

INOH website

Glycolysis Gluconeogenesis pathway

PID NCI

Cross-References

SwissProt

P18669

TrEMBL

B4DMJ7 Q6FHU2

UniProt Splice Variant

Entrez Gene

5223

UniGene

RefSeq

NM_002629

HUGO

HGNC:8888

OMIM

172250 300567

CCDS

CCDS7458

HPRD

01392

IMGT

EMBL

AK292216 AK293023 AK297491 AK312351 AY007118 BC010038 BC011678 BC053356 BC066959 BC073742 BC157873 CH471054 CH471066 CR541659 EU794644 J04173

GenPept

AAA60071 AAG01990 AAH10038 AAH11678 AAH53356 AAH66959 AAH73742 AAI57874 ACJ13698 BAF84905 BAF85712 BAG35272 BAG59909 CAG46460 EAW49938 EAW49939 EAW49944 EAW97732 EAW97734 EAW97735

RNA Seq Atlas

441531 5223