InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EXOSC1

Summary

InnateDB Gene

IDBG-84835.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EXOSC1

Gene Name

exosome component 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000171311

Encoded Proteins

IDBP-84837

exosome component 1

IDBP-84839

exosome component 1

IDBP-84841

exosome component 1

IDBP-84843

exosome component 1

IDBP-807046

exosome component 1

IDBP-807045

exosome component 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:97436142-97446017

Strand

Reverse strand

Band

q24.1

Transcripts

ENST00000370902	ENSP00000359939
ENST00000370886	ENSP00000359923
ENST00000370885	ENSP00000359922
ENST00000370884	ENSP00000359921
ENST00000477692	ENSP00000473303
ENST00000485122	ENSP00000473660
ENST00000471049
ENST00000472345
ENST00000476234
ENST00000489158
ENST00000474309

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006364	rRNA processing
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay