Version 5.4
Homo sapiens Gene: CPSF3L
Summary
InnateDB Gene IDBG-85005.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPSF3L
Gene Name cleavage and polyadenylation specific factor 3-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000127054
Encoded Proteins
IDBP-361356
cleavage and polyadenylation specific factor 3-like
IDBP-722243
IDBP-361375
cleavage and polyadenylation specific factor 3-like
IDBP-594323
cleavage and polyadenylation specific factor 3-like
IDBP-361380
cleavage and polyadenylation specific factor 3-like
IDBP-361384
cleavage and polyadenylation specific factor 3-like
IDBP-361386
cleavage and polyadenylation specific factor 3-like
IDBP-361389
cleavage and polyadenylation specific factor 3-like
IDBP-807763
cleavage and polyadenylation specific factor 3-like
IDBP-598614
cleavage and polyadenylation specific factor 3-like
IDBP-597247
cleavage and polyadenylation specific factor 3-like
IDBP-592463
cleavage and polyadenylation specific factor 3-like
IDBP-592202
cleavage and polyadenylation specific factor 3-like
IDBP-600094
cleavage and polyadenylation specific factor 3-like
IDBP-592374
cleavage and polyadenylation specific factor 3-like
IDBP-600035
cleavage and polyadenylation specific factor 3-like
IDBP-590175
cleavage and polyadenylation specific factor 3-like
IDBP-597602
cleavage and polyadenylation specific factor 3-like
IDBP-600039
cleavage and polyadenylation specific factor 3-like
IDBP-594288
cleavage and polyadenylation specific factor 3-like
IDBP-595421
cleavage and polyadenylation specific factor 3-like
IDBP-584301
cleavage and polyadenylation specific factor 3-like
IDBP-599700
cleavage and polyadenylation specific factor 3-like
IDBP-586231
cleavage and polyadenylation specific factor 3-like
IDBP-583296
cleavage and polyadenylation specific factor 3-like
IDBP-807767
cleavage and polyadenylation specific factor 3-like
IDBP-807772
cleavage and polyadenylation specific factor 3-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:1311585-1324691
Strand Reverse strand
Band p36.33
Transcripts
ENST00000323275
ENST00000435064 ENSP00000413493
ENST00000421495 ENSP00000464436
ENST00000411962 ENSP00000400548
ENST00000458452 ENSP00000433930
ENST00000450926 ENSP00000392848
ENST00000419704 ENSP00000404886
ENST00000434694 ENSP00000411233
ENST00000430786 ENSP00000404012
ENST00000429572 ENSP00000481275
ENST00000470030
ENST00000497304
ENST00000462432
ENST00000478641
ENST00000485710
ENST00000461514
ENST00000467408
ENST00000488042
ENST00000498173
ENST00000496353
ENST00000493534
ENST00000490853
ENST00000498476 ENSP00000436824
ENST00000470679 ENSP00000434782
ENST00000532772 ENSP00000431214
ENST00000527098 ENSP00000431952
ENST00000525164
ENST00000528879 ENSP00000432777
ENST00000525769
ENST00000531377 ENSP00000433264
ENST00000527383 ENSP00000431425
ENST00000531292
ENST00000531020
ENST00000533916
ENST00000526797 ENSP00000435418
ENST00000526332 ENSP00000434790
ENST00000527719 ENSP00000436743
ENST00000530031 ENSP00000432009
ENST00000526113
ENST00000526904
ENST00000525603
ENST00000534345 ENSP00000435772
ENST00000532952
ENST00000531019 ENSP00000433733
ENST00000525285 ENSP00000436396
ENST00000530233
ENST00000540437 ENSP00000445001
ENST00000545578 ENSP00000444672
ENST00000620829 ENSP00000481821
ENST00000618806 ENSP00000480957
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0008152 metabolic process
GO:0016180 snRNA processing
Cellular Component
GO:0005737 cytoplasm
GO:0032039 integrator complex
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029034
View Gene Order
ENSBTAG00000007620
Not yet available
Cross-References
SwissProt Q5TA45
TrEMBL E9PNH9 J3QRY6
UniProt Splice Variant
Entrez Gene 54973
UniGene Hs.613900 Hs.638090 Hs.6449 Hs.739302
RefSeq NM_001256460 NM_001256456 NM_001256462 NM_001256463 NM_017871 XM_005244763 XM_006710715
HUGO HGNC:26052
OMIM 611354
CCDS CCDS57959 CCDS21 CCDS57960 CCDS57961 CCDS72678
HPRD 13377
IMGT
EMBL AK000549 AK021939 AK023356 AK056652 AK291387 AK297350 AL136813 AL139287 BC000675 BC007978 BC013904 BK005673 BK005728 CH471183 CR533557
GenPept AAH00675 AAH07978 AAH13904 BAA91246 BAB13943 BAB14541 BAF84076 BAG51775 BAG59799 CAB66747 CAG38588 CAI23174 CAI23176 CAI23177 CAI23179 CAI23180 CAI23181 DAA05669 DAA05728 EAW56238 EAW56239 EAW56242
RNA Seq Atlas 102465435 102723551 54973

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca