Version 5.4
Homo sapiens Gene: PASK
Summary
InnateDB Gene IDBG-85028.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PASK
Gene Name PAS domain containing serine/threonine kinase
Synonyms PASKIN; STK37
Species Homo sapiens
Ensembl Gene ENSG00000115687
Encoded Proteins
IDBP-85030
PAS domain containing serine/threonine kinase
IDBP-85032
PAS domain containing serine/threonine kinase
IDBP-294867
PAS domain containing serine/threonine kinase
IDBP-295658
PAS domain containing serine/threonine kinase
IDBP-389626
PAS domain containing serine/threonine kinase
IDBP-389627
PAS domain containing serine/threonine kinase
IDBP-389628
PAS domain containing serine/threonine kinase
IDBP-389629
PAS domain containing serine/threonine kinase
IDBP-601164
PAS domain containing serine/threonine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:241106099-241150264
Strand Reverse strand
Band q37.3
Transcripts
ENST00000234040 ENSP00000234040
ENST00000358649 ENSP00000351475
ENST00000405260 ENSP00000384016
ENST00000403638 ENSP00000384438
ENST00000437780 ENSP00000408506
ENST00000433589 ENSP00000395672
ENST00000415234 ENSP00000400734
ENST00000452907 ENSP00000397922
ENST00000472072
ENST00000489256
ENST00000475666
ENST00000493544
ENST00000459710
ENST00000485940
ENST00000544142 ENSP00000441374
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 95 [view]
Protein-Protein 95 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0043576 regulation of respiratory gaseous exchange
GO:0045719 negative regulation of glycogen biosynthetic process
GO:0045727 positive regulation of translation
GO:0046777 protein autophosphorylation
GO:0070092 regulation of glucagon secretion
GO:2000505 regulation of energy homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026274
View Gene Order
ENSBTAG00000000785
Not yet available
Cross-References
SwissProt
TrEMBL B7Z7V7 C9J1Z3 C9J4R3 Q14148
UniProt Splice Variant
Entrez Gene 23178
UniGene Hs.397891 Hs.595204
RefSeq NM_001252120 NM_001252119 NM_001252122 NM_001252124 NM_015148 XM_005246990 XM_005246991
HUGO HGNC:17270
OMIM 607505
CCDS CCDS2545 CCDS58758 CCDS58759
HPRD 06328
IMGT
EMBL AC005237 AF067137 AF387103 AK302561 BC043495 BC050565 BC063585 CH471063 CR749231 D50925 U79240
GenPept AAB50198 AAC23506 AAH43495 AAH50565 AAH63585 AAK69752 BAA09484 BAH13743 CAH18087 EAW71238
RNA Seq Atlas 23178

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca