Version 5.4
Homo sapiens Gene: TAS1R3
Summary
InnateDB Gene IDBG-85093.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAS1R3
Gene Name taste receptor, type 1, member 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000169962
Encoded Proteins
IDBP-85095
taste receptor, type 1, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The TAS1R3 gene encodes the human homolog of mouse Sac, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharine, and other sweeteners (Max et al., 2001 [PubMed 11326277]).[supplied by OMIM, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:1331314-1335306
Strand Forward strand
Band p36.33
Transcripts
ENST00000339381 ENSP00000344411
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0008527 taste receptor activity
GO:0033041 sweet taste receptor activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001582 detection of chemical stimulus involved in sensory perception of sweet taste
GO:0007186 G-protein coupled receptor signaling pathway
GO:0050916 sensory perception of sweet taste
GO:0050917 sensory perception of umami taste
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000029072
View Gene Order
Pathways
NETPATH
REACTOME
REACT_18319
Class C/3 (Metabotropic glutamate/pheromone receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04742
Taste transduction pathway
hsa04973
Carbohydrate digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt Q7RTX0
TrEMBL
UniProt Splice Variant
Entrez Gene 83756
UniGene Hs.74375
RefSeq NM_152228
HUGO HGNC:15661
OMIM 605865
CCDS CCDS30556
HPRD
IMGT
EMBL AB065647 AL139287 BK000152
GenPept BAC05873 CAI23184 DAA00013
RNA Seq Atlas 83756

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca