InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: XIAP

Summary

InnateDB Gene

IDBG-85142.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XIAP

Gene Name

X-linked inhibitor of apoptosis

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000101966

Encoded Proteins

IDBP-11725

X-linked inhibitor of apoptosis

IDBP-85144

X-linked inhibitor of apoptosis

IDBP-380304

X-linked inhibitor of apoptosis

IDBP-380308

X-linked inhibitor of apoptosis

IDBP-380315

X-linked inhibitor of apoptosis

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18769721

XIAP regulates cytosol-specific innate immunity to Listeria infection.

PMID 19667203

XIAP interacts with NOD1 and NOD2 and mediates NOD signalling via interaction with RIPK2.

PMID 19531477

XIAP and its E3 ligase activity promote transforming growth factor-{beta}-mediated NF-kappaB activation during breast cancer progression.

PMID 20406824

X-linked inhibitor of apoptosis protein (XIAP) in a complex with survivin, a physiological substrate for granzyme M (GzmM), act to inhibit caspase activation.

PMID 21447281

XIAP facilitates ubiquitin-dependent signalling activated by pattern recognition receptors, such as TLR and NOD, to mediate the activation of NFKB transcription.

InnateDB Annotation from Orthologs

Summary

PMID 21447281

[Mus musculus] Xiap facilitates ubiquitin-dependent signalling activated by pattern recognition receptors, such as TLR and NOD, to mediate the activation of NFKB transcription.

Entrez Gene

Summary

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:123859724-123913979

Strand

Forward strand

Band

q25

Transcripts

ENST00000355640	ENSP00000347858
ENST00000371199	ENSP00000360242
ENST00000422098	ENSP00000405529
ENST00000430625	ENSP00000400637
ENST00000434753	ENSP00000395230
ENST00000481776
ENST00000497906
ENST00000468691
ENST00000497640
ENST00000468503
ENST00000496602

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 221 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	221 [view]
Protein-Protein	213 [view]
Protein-DNA	2 [view]
Protein-RNA	4 [view]
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Biological Process

GO:0006915	apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0016055	Wnt signaling pathway
GO:0016567	protein ubiquitination
GO:0030510	regulation of BMP signaling pathway
GO:0031398	positive regulation of protein ubiquitination
GO:0042127	regulation of cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045088	regulation of innate immune response
GO:0050727	regulation of inflammatory response
GO:0055070	copper ion homeostasis
GO:0070424	regulation of nucleotide-binding oligomerization domain containing signaling pathway
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:0097193	intrinsic apoptotic signaling pathway
GO:1902530	positive regulation of protein linear polyubiquitination