Version 5.4
Homo sapiens Gene: FARP2
Summary
InnateDB Gene IDBG-85151.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FARP2
Gene Name FERM, RhoGEF and pleckstrin domain protein 2
Synonyms FIR; FRG; PLEKHC3
Species Homo sapiens
Ensembl Gene ENSG00000006607
Encoded Proteins
IDBP-85153
FERM, RhoGEF and pleckstrin domain protein 2
IDBP-85155
FERM, RhoGEF and pleckstrin domain protein 2
IDBP-389691
FERM, RhoGEF and pleckstrin domain protein 2
IDBP-389692
FERM, RhoGEF and pleckstrin domain protein 2
IDBP-389693
FERM, RhoGEF and pleckstrin domain protein 2
IDBP-389694
FERM, RhoGEF and pleckstrin domain protein 2
IDBP-389695
FERM, RhoGEF and pleckstrin domain protein 2
IDBP-389696
FERM, RhoGEF and pleckstrin domain protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:241356243-241494841
Strand Forward strand
Band q37.3
Transcripts
ENST00000264042 ENSP00000264042
ENST00000373287 ENSP00000362384
ENST00000418082 ENSP00000393376
ENST00000445489 ENSP00000388167
ENST00000413432 ENSP00000412772
ENST00000422951 ENSP00000411353
ENST00000444371 ENSP00000415474
ENST00000412332 ENSP00000403437
ENST00000478489
ENST00000479427
ENST00000492868
ENST00000464142
ENST00000473082
ENST00000467260
ENST00000471447
ENST00000485051
ENST00000476799
ENST00000473510
ENST00000496470
ENST00000491425
ENST00000486736
ENST00000470617
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0008092 cytoskeletal protein binding
GO:0030676 Rac guanyl-nucleotide exchange factor activity
Biological Process
GO:0007155 cell adhesion
GO:0007411 axon guidance
GO:0016322 neuron remodeling
GO:0016601 Rac protein signal transduction
GO:0030316 osteoclast differentiation
GO:0031532 actin cytoskeleton reorganization
GO:0032314 regulation of Rac GTPase activity
GO:0032321 positive regulation of Rho GTPase activity
GO:0032855 positive regulation of Rac GTPase activity
GO:0033623 regulation of integrin activation
GO:0035023 regulation of Rho protein signal transduction
GO:0071526 semaphorin-plexin signaling pathway
GO:0071800 podosome assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0019898 extrinsic component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000034066
View Gene Order
Pathways
NETPATH
REACTOME
REACT_19279
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04520
Adherens junction pathway
INOH
PID NCI
nectin_pathway
Nectin adhesion pathway
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.726316
RefSeq NM_001282983 NM_001282984 NM_014808 XM_005247049
HUGO
OMIM
CCDS CCDS33424 CCDS63197
HPRD 16885
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca