Version 5.4
Homo sapiens Gene: MAPKAP1
Summary
InnateDB Gene IDBG-85219.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAPKAP1
Gene Name mitogen-activated protein kinase associated protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000119487
Encoded Proteins
IDBP-85221
mitogen-activated protein kinase associated protein 1
IDBP-85223
mitogen-activated protein kinase associated protein 1
IDBP-85225
mitogen-activated protein kinase associated protein 1
IDBP-85229
mitogen-activated protein kinase associated protein 1
IDBP-85231
mitogen-activated protein kinase associated protein 1
IDBP-85235
mitogen-activated protein kinase associated protein 1
IDBP-242319
mitogen-activated protein kinase associated protein 1
IDBP-242321
mitogen-activated protein kinase associated protein 1
IDBP-380438
mitogen-activated protein kinase associated protein 1
IDBP-380439
mitogen-activated protein kinase associated protein 1
IDBP-380441
mitogen-activated protein kinase associated protein 1
IDBP-380447
mitogen-activated protein kinase associated protein 1
IDBP-475880
mitogen-activated protein kinase associated protein 1
IDBP-484922
mitogen-activated protein kinase associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:125437393-125707234
Strand Reverse strand
Band q33.3
Transcripts
ENST00000265960 ENSP00000265960
ENST00000350766 ENSP00000265961
ENST00000373511 ENSP00000362610
ENST00000373503 ENSP00000362602
ENST00000373498 ENSP00000362597
ENST00000373496 ENSP00000362595
ENST00000394063 ENSP00000377627
ENST00000394060 ENSP00000377624
ENST00000444226 ENSP00000412485
ENST00000420643 ENSP00000400182
ENST00000437973
ENST00000427078 ENSP00000408359
ENST00000448439
ENST00000433483 ENSP00000390024
ENST00000483937
ENST00000497932 ENSP00000418607
ENST00000496658
ENST00000496063
ENST00000473837
ENST00000468896 ENSP00000417766
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 54 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0017016 Ras GTPase binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0070300 phosphatidic acid binding
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
Biological Process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0021762 substantia nigra development
GO:0031295 T cell costimulation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038696
View Gene Order
ENSBTAG00000010271
Not yet available
Pathways
NETPATH
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_19358
CD28 dependent PI3K/Akt signaling pathway
REACT_19183
CD28 co-stimulation pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_12529
Signaling by VEGF pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
KEGG
INOH
INOH website
Insulin receptor signaling pathway
PID NCI
pi3kciaktpathway
Class I PI3K signaling events mediated by Akt
cxcr4_pathway
CXCR4-mediated signaling events
erbb1_downstream_pathway
ErbB1 downstream signaling
mtor_4pathway
mTOR signaling pathway
cxcr3pathway
CXCR3-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.495138 Hs.597362 Hs.629072
RefSeq NM_001006617 NM_001006618 NM_001006619 NM_001006620 NM_001006621 NM_024117
HUGO
OMIM
CCDS CCDS35139 CCDS35140 CCDS35141 CCDS48020 CCDS6864
HPRD 17464
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca