Version 5.4
Homo sapiens Gene: DTYMK
Summary
InnateDB Gene IDBG-85276.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DTYMK
Gene Name deoxythymidylate kinase (thymidylate kinase)
Synonyms CDC8; PP3731; TMPK; TYMK
Species Homo sapiens
Ensembl Gene ENSG00000168393
Encoded Proteins
IDBP-85278
deoxythymidylate kinase (thymidylate kinase)
IDBP-227463
deoxythymidylate kinase (thymidylate kinase)
IDBP-389724
deoxythymidylate kinase (thymidylate kinase)
IDBP-389725
deoxythymidylate kinase (thymidylate kinase)
IDBP-389726
deoxythymidylate kinase (thymidylate kinase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:241675742-241686991
Strand Reverse strand
Band q37.3
Transcripts
ENST00000305784 ENSP00000304802
ENST00000400770 ENSP00000383581
ENST00000445261 ENSP00000408939
ENST00000432348 ENSP00000410647
ENST00000420144 ENSP00000387379
ENST00000493095
ENST00000464603
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0050145 nucleoside phosphate kinase activity
Biological Process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0007049 cell cycle
GO:0008283 cell proliferation
GO:0009165 nucleotide biosynthetic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0016310 phosphorylation
GO:0043627 response to estrogen
GO:0044281 small molecule metabolic process
GO:0045445 myoblast differentiation
GO:0046686 response to cadmium ion
GO:0046939 nucleotide phosphorylation
GO:0046940 nucleoside monophosphate phosphorylation
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0071363 cellular response to growth factor stimulus
Cellular Component
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026281
View Gene Order
ENSBTAG00000015408
Not yet available
Pathways
NETPATH
REACTOME
REACT_21330
Synthesis and interconversion of nucleotide di- and triphosphates pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_111217
Metabolism pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
INOH
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001165031 NM_012145
HUGO
OMIM
CCDS CCDS2552
HPRD 01773
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca