InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SMARCA1

Summary

InnateDB Gene

IDBG-85456.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMARCA1

Gene Name

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

Synonyms

ISWI; NURF140; SNF2L; SNF2L1; SNF2LB; SNF2LT; SWI; SWI2

Species

Homo sapiens

Ensembl Gene

ENSG00000102038

Encoded Proteins

IDBP-85458

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

IDBP-85460

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

IDBP-85464

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the SWI/SNF family of proteins. The encoded protein is an ATPase which is expressed in diverse tissues and contributes to the chromatin remodeling complex that is involved in transcription. The protein may also play a role in DNA damage, growth inhibition and apoptosis of cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:129446501-129523500

Strand

Reverse strand

Band

q26.1

Transcripts

ENST00000371122	ENSP00000360163
ENST00000371123	ENSP00000360164
ENST00000371121	ENSP00000360162
ENST00000478420
ENST00000617310

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity
GO:0016787	hydrolase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0031491	nucleosome binding
GO:0036310	annealing helicase activity
GO:0070615	nucleosome-dependent ATPase activity

Biological Process

GO:0000733	DNA strand renaturation
GO:0006200	ATP catabolic process
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0007420	brain development
GO:0030182	neuron differentiation
GO:0043044	ATP-dependent chromatin remodeling
GO:0045893	positive regulation of transcription, DNA-templated
GO:2000177	regulation of neural precursor cell proliferation

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0016589	NURF complex
GO:0090537	CERF complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031099

View Gene Order

ENSBTAG00000002292

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001282874 NM_001282875 NM_003069 XM_005262461

HUGO

OMIM

CCDS

CCDS14612 CCDS76018 CCDS76019

HPRD

02055

IMGT

EMBL

GenPept

RNA Seq Atlas