InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PIM1

Summary

InnateDB Gene

IDBG-85488.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIM1

Gene Name

pim-1 oncogene

Synonyms

PIM

Species

Homo sapiens

Ensembl Gene

ENSG00000137193

Encoded Proteins

IDBP-85490

pim-1 oncogene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:37170203-37175426

Strand

Forward strand

Band

p21.2

Transcripts

ENST00000373509	ENSP00000362608
ENST00000468243
ENST00000479509

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	43 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0030145	manganese ion binding
GO:0043024	ribosomal small subunit binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0007275	multicellular organismal development
GO:0008283	cell proliferation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0030212	hyaluronan metabolic process
GO:0031659	positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0043066	negative regulation of apoptotic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024014

View Gene Order

ENSBTAG00000000396

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa05221

Acute myeloid leukemia pathway

hsa04630

Jak-STAT signaling pathway pathway

INOH

PID NCI

myc_activpathway

Validated targets of C-MYC transcriptional activation

cmyb_pathway

C-MYB transcription factor network

il3_pathway

IL3-mediated signaling events

nfat_3pathway

Role of Calcineurin-dependent NFAT signaling in lymphocytes

gmcsf_pathway

GMCSF-mediated signaling events

il5_pathway

IL5-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.604537 Hs.81170

RefSeq

NM_001243186 NM_002648

HUGO

OMIM

CCDS

CCDS4830

HPRD

01292

IMGT

EMBL

GenPept

RNA Seq Atlas