Version 5.4
Homo sapiens Gene: ICA1
Summary
InnateDB Gene IDBG-8551.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ICA1
Gene Name islet cell autoantigen 1, 69kDa
Synonyms ICA69; ICAp69
Species Homo sapiens
Ensembl Gene ENSG00000003147
Encoded Proteins
IDBP-8553
islet cell autoantigen 1, 69kDa
IDBP-8555
islet cell autoantigen 1, 69kDa
IDBP-8557
islet cell autoantigen 1, 69kDa
IDBP-236992
islet cell autoantigen 1, 69kDa
IDBP-292778
islet cell autoantigen 1, 69kDa
IDBP-292781
islet cell autoantigen 1, 69kDa
IDBP-292780
islet cell autoantigen 1, 69kDa
IDBP-292776
islet cell autoantigen 1, 69kDa
IDBP-364972
islet cell autoantigen 1, 69kDa
IDBP-364981
islet cell autoantigen 1, 69kDa
IDBP-364984
islet cell autoantigen 1, 69kDa
IDBP-364987
islet cell autoantigen 1, 69kDa
IDBP-364988
islet cell autoantigen 1, 69kDa
IDBP-364991
islet cell autoantigen 1, 69kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren\'s syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:8113184-8262687
Strand Reverse strand
Band p21.3
Transcripts
ENST00000265577 ENSP00000265577
ENST00000339809 ENSP00000341603
ENST00000317367 ENSP00000316074
ENST00000396675 ENSP00000379908
ENST00000406470 ENSP00000385651
ENST00000402384 ENSP00000385570
ENST00000401396 ENSP00000385305
ENST00000407906 ENSP00000386021
ENST00000455539 ENSP00000410341
ENST00000422063 ENSP00000403982
ENST00000447326 ENSP00000398435
ENST00000430867 ENSP00000397496
ENST00000457755 ENSP00000393314
ENST00000446305 ENSP00000406722
ENST00000486677
ENST00000470696
ENST00000490041
ENST00000476942
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0019904 protein domain specific binding
Biological Process
GO:0006836 neurotransmitter transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030054 cell junction
GO:0030658 transport vesicle membrane
GO:0030667 secretory granule membrane
GO:0030672 synaptic vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062995
View Gene Order
ENSBTAG00000000799
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04940
Type I diabetes mellitus pathway
INOH
PID NCI
Cross-References
SwissProt Q05084
TrEMBL A0A024RA29 C9J3Y4 F8WET5 Q9UDQ6
UniProt Splice Variant
Entrez Gene 3382
UniGene Hs.487561 Hs.718069
RefSeq NM_022307 NM_001136020 NM_001276478 NM_004968 XM_005249735 XM_005249736 XM_006715717 XM_006715718 XM_006715719 XM_006715720 XM_006715721
HUGO HGNC:5343
OMIM 147625
CCDS CCDS34602 CCDS64595
HPRD 00971
IMGT
EMBL AC006042 AC007009 AK292106 CH471073 EU416199 L01100 L21181 U26591 U37183 U71251 U71252 U71253 U71255 U71256 U71257 U71258 U71259 U71260 U71261 U71262 U71263 U71264
GenPept AAA02564 AAA64927 AAB19033 AAB94738 AAC50935 AAD50515 ACB47390 BAF84795 EAW93610 EAW93611 EAW93617 EAW93619 EAW93620
RNA Seq Atlas 3382

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca