Version 5.4
Homo sapiens Gene: MIB2
Summary
InnateDB Gene IDBG-85549.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MIB2
Gene Name mindbomb E3 ubiquitin protein ligase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197530
Encoded Proteins
IDBP-85555
mindbomb homolog 2 (Drosophila)
IDBP-85557
mindbomb homolog 2 (Drosophila)
IDBP-85565
mindbomb homolog 2 (Drosophila)
IDBP-483021
mindbomb homolog 2 (Drosophila)
IDBP-482807
mindbomb homolog 2 (Drosophila)
IDBP-475060
mindbomb homolog 2 (Drosophila)
IDBP-480174
mindbomb homolog 2 (Drosophila)
IDBP-480705
mindbomb homolog 2 (Drosophila)
IDBP-478645
mindbomb homolog 2 (Drosophila)
IDBP-483741
mindbomb homolog 2 (Drosophila)
IDBP-479891
mindbomb homolog 2 (Drosophila)
IDBP-480228
mindbomb homolog 2 (Drosophila)
IDBP-475010
mindbomb homolog 2 (Drosophila)
IDBP-483194
mindbomb homolog 2 (Drosophila)
IDBP-480910
mindbomb homolog 2 (Drosophila)
IDBP-722446
IDBP-721868
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:1615415-1630610
Strand Forward strand
Band p36.33
Transcripts
ENST00000378712 ENSP00000367984
ENST00000355826 ENSP00000348081
ENST00000378708 ENSP00000367980
ENST00000520777 ENSP00000428660
ENST00000518681 ENSP00000428264
ENST00000505820 ENSP00000426103
ENST00000479659
ENST00000489635 ENSP00000426007
ENST00000511502
ENST00000477990
ENST00000514363 ENSP00000420935
ENST00000487053 ENSP00000424615
ENST00000502470 ENSP00000423221
ENST00000507082
ENST00000463492
ENST00000510793 ENSP00000426865
ENST00000504599 ENSP00000426128
ENST00000507229
ENST00000503789 ENSP00000426603
ENST00000506488 ENSP00000425032
ENST00000512004
ENST00000508455
ENST00000514234 ENSP00000427680
ENST00000467597
ENST00000508148
ENST00000486072 ENSP00000463504
ENST00000505370
ENST00000473511
ENST00000464570
ENST00000483015 ENSP00000464106
ENST00000511910
ENST00000470373
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004842 ubiquitin-protein transferase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0007219 Notch signaling pathway
GO:0016567 protein ubiquitination
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005769 early endosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029060
View Gene Order
ENSBTAG00000010720
Not yet available
Pathways
NETPATH
REACTOME
REACT_118614
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_160205
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
REACT_160089
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_118721
Signaling by NOTCH2 pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.135805
RefSeq NM_001170686 NM_001170687 NM_001170688 NM_001170689 NM_080875 XM_006710368 XM_006710370 XM_006710372
HUGO
OMIM
CCDS CCDS41224 CCDS53261 CCDS53262 CCDS53263 CCDS53264
HPRD 15905
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca