InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BIRC7

Summary

InnateDB Gene

IDBG-85846.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BIRC7

Gene Name

baculoviral IAP repeat containing 7

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000101197

Encoded Proteins

IDBP-85848

baculoviral IAP repeat containing 7

IDBP-85852

baculoviral IAP repeat containing 7

IDBP-239825

baculoviral IAP repeat containing 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:63235883-63240507

Strand

Forward strand

Band

q13.33

Transcripts

ENST00000217169	ENSP00000217169
ENST00000342412	ENSP00000345213
ENST00000395306	ENSP00000378717

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	30 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0019899	enzyme binding

Biological Process

GO:0006915	apoptotic process
GO:0007257	activation of JUN kinase activity
GO:0010951	negative regulation of endopeptidase activity
GO:0016567	protein ubiquitination
GO:0042127	regulation of cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0070247	regulation of natural killer cell apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038840

View Gene Order

ENSBTAG00000004911

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04210

Apoptosis pathway

hsa04120

Ubiquitin mediated proteolysis pathway

hsa05222

Small cell lung cancer pathway

hsa05200

Pathways in cancer pathway

hsa05145

Toxoplasmosis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

A8MTF4

UniProt Splice Variant

Entrez Gene

79444

UniGene

Hs.256126

RefSeq

NM_022161 NM_139317

HUGO

HGNC:13702

OMIM

605737

CCDS

CCDS13512 CCDS13513

HPRD

05761

IMGT

EMBL

AL121827

GenPept

RNA Seq Atlas

79444