InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRKCZ

Summary

InnateDB Gene

IDBG-86108.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKCZ

Gene Name

protein kinase C, zeta

Synonyms

PKC-ZETA; PKC2

Species

Homo sapiens

Ensembl Gene

ENSG00000067606

Encoded Proteins

IDBP-86110

protein kinase C, zeta

IDBP-227086

protein kinase C, zeta

IDBP-227088

protein kinase C, zeta

IDBP-481812

protein kinase C, zeta

IDBP-480046

protein kinase C, zeta

IDBP-473735

protein kinase C, zeta

IDBP-473488

protein kinase C, zeta

IDBP-721996

IDBP-474508

protein kinase C, zeta

IDBP-481720

protein kinase C, zeta

IDBP-478800

protein kinase C, zeta

IDBP-484427

protein kinase C, zeta

IDBP-482291

protein kinase C, zeta

IDBP-483574

protein kinase C, zeta

IDBP-483209

protein kinase C, zeta

IDBP-477566

protein kinase C, zeta

IDBP-477257

protein kinase C, zeta

IDBP-483545

protein kinase C, zeta

IDBP-476070

protein kinase C, zeta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:2050470-2185395

Strand

Forward strand

Band

p36.33

Transcripts

ENST00000378567	ENSP00000367830
ENST00000400921	ENSP00000383712
ENST00000400920	ENSP00000383711
ENST00000419838
ENST00000468310	ENSP00000424945
ENST00000484419
ENST00000503297	ENSP00000421587
ENST00000479566
ENST00000466651
ENST00000495347	ENSP00000427085
ENST00000461106	ENSP00000426412
ENST00000461465	ENSP00000462105
ENST00000470596	ENSP00000424228
ENST00000496325	ENSP00000421869
ENST00000481140	ENSP00000425643
ENST00000482686	ENSP00000425317
ENST00000486681	ENSP00000424763
ENST00000470986	ENSP00000421219
ENST00000470511	ENSP00000421350
ENST00000471018	ENSP00000422349
ENST00000466352	ENSP00000427134
ENST00000497183	ENSP00000422764
ENST00000479263
ENST00000503672
ENST00000478770	ENSP00000424398
ENST00000505322
ENST00000472017

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 171 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	171 [view]
Protein-Protein	170 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004697	protein kinase C activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0015459	potassium channel regulator activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0043274	phospholipase binding
GO:0043560	insulin receptor substrate binding
GO:0046872	metal ion binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0001954	positive regulation of cell-matrix adhesion
GO:0006468	protein phosphorylation
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007596	blood coagulation
GO:0007616	long-term memory
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0016477	cell migration
GO:0018105	peptidyl-serine phosphorylation
GO:0030010	establishment of cell polarity
GO:0030168	platelet activation
GO:0031333	negative regulation of protein complex assembly
GO:0031532	actin cytoskeleton reorganization
GO:0031584	activation of phospholipase D activity
GO:0032148	activation of protein kinase B activity
GO:0032753	positive regulation of interleukin-4 production
GO:0032869	cellular response to insulin stimulus
GO:0034613	cellular protein localization
GO:0035556	intracellular signal transduction
GO:0043066	negative regulation of apoptotic process
GO:0045630	positive regulation of T-helper 2 cell differentiation
GO:0046326	positive regulation of glucose import
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0046628	positive regulation of insulin receptor signaling pathway
GO:0047496	vesicle transport along microtubule
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0050806	positive regulation of synaptic transmission
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051222	positive regulation of protein transport
GO:0051291	protein heterooligomerization
GO:0051346	negative regulation of hydrolase activity
GO:0051899	membrane depolarization
GO:0060081	membrane hyperpolarization
GO:0060291	long-term synaptic potentiation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070528	protein kinase C signaling
GO:0072659	protein localization to plasma membrane
GO:1990138	neuron projection extension
GO:2000463	positive regulation of excitatory postsynaptic membrane potential
GO:2000553	positive regulation of T-helper 2 cell cytokine production
GO:2000664	positive regulation of interleukin-5 secretion
GO:2000667	positive regulation of interleukin-13 secretion
GO:2001181	positive regulation of interleukin-10 secretion

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0005938	cell cortex
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0016363	nuclear matrix
GO:0030054	cell junction
GO:0031252	cell leading edge
GO:0031941	filamentous actin
GO:0035748	myelin sheath abaxonal region
GO:0043203	axon hillock
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0045179	apical cortex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome