Version 5.4
Homo sapiens Gene: KCNK16
Summary
InnateDB Gene IDBG-86196.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNK16
Gene Name potassium channel, subfamily K, member 16
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000095981
Encoded Proteins
IDBP-86198
potassium channel, subfamily K, member 16
IDBP-86200
potassium channel, subfamily K, member 16
IDBP-377739
potassium channel, subfamily K, member 16
IDBP-377740
potassium channel, subfamily K, member 16
IDBP-476739
potassium channel, subfamily K, member 16
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:39314698-39322968
Strand Reverse strand
Band p21.2
Transcripts
ENST00000373229 ENSP00000362326
ENST00000373227 ENSP00000362324
ENST00000425054 ENSP00000391498
ENST00000437525 ENSP00000415375
ENST00000507712 ENSP00000423842
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005267 potassium channel activity
Biological Process
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023387
View Gene Order
ENSBTAG00000010352
Not yet available
Pathways
NETPATH
REACTOME
REACT_75850
TWIK-related alkaline pH activated K+ channel (TALK) pathway
REACT_75897
Tandem pore domain potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.287765
RefSeq NM_001135105 NM_001135106 NM_001135107 NM_032115
HUGO
OMIM
CCDS CCDS47420 CCDS47421 CCDS47422 CCDS4843
HPRD 09565
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca