Version 5.4
Homo sapiens Gene: PEX10
Summary
InnateDB Gene IDBG-86255.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PEX10
Gene Name peroxisomal biogenesis factor 10
Synonyms NALD; PBD6A; PBD6B; RNF69
Species Homo sapiens
Ensembl Gene ENSG00000157911
Encoded Proteins
IDBP-86257
peroxisomal biogenesis factor 10
IDBP-363046
peroxisomal biogenesis factor 10
IDBP-474782
peroxisomal biogenesis factor 10
IDBP-478461
peroxisomal biogenesis factor 10
IDBP-722183
IDBP-722480
IDBP-481556
peroxisomal biogenesis factor 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein involved in import of peroxisomal matrix proteins. This protein localizes to the peroxisomal membrane. Mutations in this gene result in phenotypes within the Zellweger spectrum of peroxisomal biogenesis disorders, ranging from neonatal adrenoleukodystrophy to Zellweger syndrome. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:2403964-2413797
Strand Reverse strand
Band p36.32
Transcripts
ENST00000288774 ENSP00000288774
ENST00000447513 ENSP00000407922
ENST00000507596 ENSP00000424291
ENST00000510434 ENSP00000423051
ENST00000508384 ENSP00000464289
ENST00000515760
ENST00000502666 ENSP00000461951
ENST00000504111
ENST00000514502 ENSP00000425924
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0007031 peroxisome organization
GO:0016558 protein import into peroxisome matrix
Cellular Component
GO:0005622 intracellular
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005779 integral component of peroxisomal membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029047
View Gene Order
ENSBTAG00000009309
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.732228
RefSeq NM_002617 NM_153818
HUGO
OMIM
CCDS CCDS41 CCDS44045
HPRD 04175
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca